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4-phosphoerythronate dehydrogenase activity

Known as: 4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity, PdxB, 4-O-phosphoerythronate dehydrogenase activity 
Catalysis of the reaction: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H(+) + NADH. [EC:1.1.1.290, RHEA:18832]
National Institutes of Health

Papers overview

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2016
2016
Accumulation of metabolic side products might favor the production of ethanol in Pho13 knockout strains
Enzymes of intermediary metabolism are very specific. However, they are not absolutely specific, although some biochemistry… Expand
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Highly Cited
2010
Highly Cited
2010
Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5′-phosphate synthesis
Overexpression of seven different genes restores growth of a ΔpdxB strain of E. coli, which cannot make pyridoxal phosphate (PLP… Expand
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2010
2010
Multiple turnovers of the nicotino-enzyme PdxB require α-keto acids as cosubstrates.
PdxB catalyzes the second step in the biosynthesis of pyridoxal phosphate by oxidizing 4-phospho-d-erythronate (4PE) to 2-oxo-3… Expand
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2007
2007
Crystal structure of D-erythronate-4-phosphate dehydrogenase complexed with NAD.
Pyridoxal-5'-phosphate (the active form of vitamin B6) is an essential cofactor in many enzymatic reactions. While animals lack… Expand
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2002
2002
Positive growth rate-dependent regulation of the pdxA, ksgA, and pdxB genes of Escherichia coli K-12.
We found that transcription of the pdxA and pdxB genes, which mediate steps in the biosynthesis of the essential coenzyme… Expand
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1992
1992
Suppression of insertions in the complex pdxJ operon of Escherichia coli K-12 by lon and other mutations.
Complementation analyses using minimal recombinant clones showed that all known pdx point mutations, which cause pyridoxine… Expand
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1990
1990
Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12.
We propose a pathway leading from erythrose-4-phosphate and glutamate to nitrogen 1 and carbons 5,5', and 6 of the pyridoxine… Expand
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1989
1989
Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12.
We report the DNA sequence and in vivo transcription start of pdxB, which encodes a protein required for de novo biosynthesis of… Expand
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1987
1987
Structural analysis of the Escherichia coli K-12 hisT operon by using a kanamycin resistance cassette.
We constructed a series of recombinant plasmids containing a kanamycin resistance (Kmr) cassette upstream from, within, and… Expand
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1987
1987
An unusual genetic link between vitamin B6 biosynthesis and tRNA pseudouridine modification in Escherichia coli K-12.
We characterized several unusual phenotypes caused by stable insertion mutations in a gene that is located upstream in the same… Expand
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