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4-phosphoerythronate dehydrogenase activity

Known as: 4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity, PdxB, 4-O-phosphoerythronate dehydrogenase activity 
Catalysis of the reaction: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H(+) + NADH. [EC:1.1.1.290, RHEA:18832]
National Institutes of Health

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2016
2016
Enzymes of intermediary metabolism are very specific. However, they are not absolutely specific, although some biochemistry… Expand
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Highly Cited
2010
Highly Cited
2010
Overexpression of seven different genes restores growth of a ΔpdxB strain of E. coli, which cannot make pyridoxal phosphate (PLP… Expand
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2010
2010
PdxB catalyzes the second step in the biosynthesis of pyridoxal phosphate by oxidizing 4-phospho-d-erythronate (4PE) to 2-oxo-3… Expand
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2007
2007
Pyridoxal-5'-phosphate (the active form of vitamin B6) is an essential cofactor in many enzymatic reactions. While animals lack… Expand
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2002
2002
We found that transcription of the pdxA and pdxB genes, which mediate steps in the biosynthesis of the essential coenzyme… Expand
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1992
1992
Complementation analyses using minimal recombinant clones showed that all known pdx point mutations, which cause pyridoxine… Expand
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1990
1990
We propose a pathway leading from erythrose-4-phosphate and glutamate to nitrogen 1 and carbons 5,5', and 6 of the pyridoxine… Expand
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1989
1989
We report the DNA sequence and in vivo transcription start of pdxB, which encodes a protein required for de novo biosynthesis of… Expand
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1987
1987
We constructed a series of recombinant plasmids containing a kanamycin resistance (Kmr) cassette upstream from, within, and… Expand
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1987
1987
We characterized several unusual phenotypes caused by stable insertion mutations in a gene that is located upstream in the same… Expand
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