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4-phosphoerythronate dehydrogenase activity

Known as: 4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity, PdxB, 4-O-phosphoerythronate dehydrogenase activity 
Catalysis of the reaction: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H(+) + NADH. [EC:1.1.1.290, RHEA:18832]
National Institutes of Health

Papers overview

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2019
2019
Significance The evolution of new metabolic pathways has been a driver of diversification from the last universal common ancestor… Expand
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Highly Cited
2010
Highly Cited
2010
Bacterial genomes encode hundreds to thousands of enzymes, most of which are specialized for particular functions. However, most… Expand
2010
2010
PdxB catalyzes the second step in the biosynthesis of pyridoxal phosphate by oxidizing 4-phospho-d-erythronate (4PE) to 2-oxo-3… Expand
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2007
2007
Pyridoxal-5'-phosphate (the active form of vitamin B6) is an essential cofactor in many enzymatic reactions. While animals lack… Expand
2002
2002
We found that transcription of the pdxA and pdxB genes, which mediate steps in the biosynthesis of the essential coenzyme… Expand
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Highly Cited
1992
Highly Cited
1992
Complementation analyses using minimal recombinant clones showed that all known pdx point mutations, which cause pyridoxine… Expand
Highly Cited
1990
Highly Cited
1990
We propose a pathway leading from erythrose-4-phosphate and glutamate to nitrogen 1 and carbons 5,5', and 6 of the pyridoxine… Expand
1989
1989
We report the DNA sequence and in vivo transcription start of pdxB, which encodes a protein required for de novo biosynthesis of… Expand
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1987
1987
We constructed a series of recombinant plasmids containing a kanamycin resistance (Kmr) cassette upstream from, within, and… Expand
1987
1987
We characterized several unusual phenotypes caused by stable insertion mutations in a gene that is located upstream in the same… Expand
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