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4-methoxyestradiol

Known as: Estra-1,3,5(10)-Triene-3,17-Diol, 4-Methoxy-, (17beta)-, 4-MeE2, 4-MeOE2 
An endogenous metabolite formed during the O-methylation of the highly carcinogenic catechol estrogen 4-hydroxyestradiol (4-OHE2) by catechol-O… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Estradiol
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Estradiol-17&bgr; and its Cytochrome P450- and Catechol-O-Methyltransferase–Derived Metabolites Selectively Stimulate Production of Prostacyclin in Uterine Artery Endothelial Cells: Role of Estrogen…
Metabolism of estradiol-17&bgr; to 2-hydroxyestradiol, 4-hydroxyestradiol, 2-methoxyestradiol, and 4-methoxyestradiol contributes… 
2011
2011
Quantitative analysis of estrogens and estrogen metabolites in endogenous MCF-7 breast cancer cells by liquid chromatography-tandem mass spectrometry.
2007
2007
Catechol-O-Methyltransferase and Methoxyestradiols Participate in the Intraoviductal Nongenomic Pathway Through Which Estradiol Accelerates Egg Transport in Cycling Rats1
Abstract Estradiol (E2) accelerates oviductal egg transport through intraoviductal nongenomic pathways in cyclic rats and through… 
2004
2004
A comparative study on the effects of 2,3,7,8,-tetrachlorodibenzo-p-dioxin polychlorinated biphenyl126 and estrogen in human bronchial epithelial cells.
2004
2004
A gas chromatography/mass spectrometry assay to measure estradiol, catecholestradiols, and methoxyestradiols in plasma
2001
2001
COMT Isoforms Catechol Estrogens : Comparison of Wild-Type and Variant-Methyltransferase ( COMT )-mediated Metabolism of O Catechol-Updated Version
The oxidative metabolism of 17 -estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and… 
Highly Cited
2000
Highly Cited
2000
SULT1A1 catalyzes 2-methoxyestradiol sulfonation in MCF-7 breast cancer cells.
In a previous study of nine human breast-derived cell lines, rates of metabolism of 17beta-estradiol (E(2)) were greatly enhanced… 
1986
1986
Relative binding of certain steroids of low polarity to human sex hormone—Binding globulin: Strong binding of 2-methoxyestrone, a steroid lacking the 17β-oh group
1984
1984
Effects of catechol estrogen methyl ethers on lipid metabolism in prepubertal rats
Highly Cited
1979
Highly Cited
1979
Impact of continuously administered catechol estrogens on uterine growth and luteinizing hormone secretion.
The biological activity of a series of natural catechol estrogens was examined under conditions of continuous administration. 2… 
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