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4-demethylwyosine

National Institutes of Health

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2 relations

Broader (1)

Guanosine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Characterization of 4-demethylwyosine Synthase, a Radical S-adenosyl-l-methionine Enzyme Involved in the Modification of tRNA
Review
2014
Review
2014
Biosynthesis of wyosine derivatives in tRNAPhe of Archaea: role of a remarkable bifunctional tRNAPhe:m1G/imG2 methyltransferase
The peculiar methyltransferase aTrm5a catalyzes two distinct reactions: N1-methylation of guanosine and C7-methylation of 4… 
2014
2014
Modification de macromolécules par insertion radicalaire. Etude de la méthylthiotransférase RimO et de la 4-demethylwyosine synthase TYW1 appartenant toutes deux à la superfamille Radical SAM.
Ces vingt dernieres annees, les reactions d'insertion d'atomes ou de fragments moleculaires dans des liaisons C-H peu reactives… 
Review
2013
Review
2013
Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine.
2012
2012
4-Demethylwyosine Synthase from Pyrococcus abyssi Is a Radical-S-adenosyl-l-methionine Enzyme with an Additional [4Fe-4S]+2 Cluster That Interacts with the Pyruvate Co-substrate*
Background: 4-Demethylwyosine synthase (TYW1) is a tRNA-modifying metalloenzyme involved in the biosynthesis of wyosine. Results… 
2011
2011
Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine.
TYW1 catalyzes the condensation of N-methylguanosine with two carbon atoms from an unknown second substrate to form 4… 
Highly Cited
2010
Highly Cited
2010
Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse pathway in Archaea.
Wyosine (imG) and its derivatives such as wybutosine (yW) are found at position 37 of phenylalanine-specific transfer RNA (tRNA… 
2005
2005
A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA.
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