4-coumarate-CoA ligase activity

Known as: 4-coumaroyl-CoA synthetase activity, 4-coumarate:CoA ligase activity, 4-coumarate:CoA ligase (AMP-forming) 
Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA. [EC:6.2.1.12]
National Institutes of Health

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4-Coumarate-CoA ligase

Papers overview

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2012
2012
Contribution of CoA ligases to benzenoid biosynthesis in petunia flowers.
Biosynthesis of benzoic acid from Phe requires shortening of the side chain by two carbons, which can occur via the β-oxidative… (More)
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2012
2012
Brown midrib2 (Bmr2) encodes the major 4-coumarate:coenzyme A ligase involved in lignin biosynthesis in sorghum (Sorghum bicolor (L.) Moench).
Successful modification of plant cell-wall composition without compromising plant integrity is dependent on being able to modify… (More)
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Highly Cited
2011
Highly Cited
2011
Silencing of 4-coumarate:coenzyme A ligase in switchgrass leads to reduced lignin content and improved fermentable sugar yields for biofuel production.
• The lignin content of feedstock has been proposed as one key agronomic trait impacting biofuel production from lignocellulosic… (More)
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2007
2007
Enzymatic Synthesis of Phenolic CoAs Using 4-Coumarate : coenzyme A Ligase ( 4 CL ) from Rice
Generally, biological synthesis using enzymes or cells has an advantage over chemical synthesis for compounds requiring chirality… (More)
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Highly Cited
2006
Highly Cited
2006
Multi-site genetic modulation of monolignol biosynthesis suggests new routes for formation of syringyl lignin and wall-bound ferulic acid in alfalfa (Medicago sativa L.).
Genes encoding seven enzymes of the monolignol pathway were independently downregulated in alfalfa (Medicago sativa) using… (More)
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Highly Cited
1996
Highly Cited
1996
Alterations in the biosynthesis of lignin in transgenic plants with chimeric genes for 4-coumarate: coenzyme A ligase.
The introduction of chimeric sense and antisense gene constructs for 4-coumarate:coenzyme A ligase into tobacco plants caused the… (More)
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Highly Cited
1996
Highly Cited
1996
Two divergent members of a tobacco 4-coumarate:coenzyme A ligase (4CL) gene family. cDNA structure, gene inheritance and expression, and properties of recombinant proteins.
Several cDNA clones encoding 4-coumarate:coenzyme A ligase (4CL) were isolated from a tobacco (Nicotiana tabacum) cDNA library… (More)
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1991
1991
Structural comparison, modes of expression, and putative cis-acting elements of the two 4-coumarate: CoA ligase genes in potato.
4-Coumarate:CoA ligase (4CL), a key enzyme of phenylpropanoid metabolism in plants, is encoded in potato (Solanum tuberosum L… (More)
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Highly Cited
1984
Highly Cited
1984
Induction of phenylalanine ammonia-lyase and 4-coumarate:CoA ligase mRNAs in cultured plant cells by UV light or fungal elicitor.
The mRNAs encoding two enzymes of phenylpropanoid metabolism, phenylalanine ammonia-lyase (PAL; EC 4.3.1.5) and 4-coumarate:CoA… (More)
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Highly Cited
1971
Highly Cited
1971
Adaptation of muscle to exercise. Increase in levels of palmityl Coa synthetase, carnitine palmityltransferase, and palmityl Coa dehydrogenase, and in the capacity to oxidize fatty acids.
The capacity of gastrocnemius and quadriceps muscles to oxidize palmitate, oleate, linoleate, palmityl CoA, and palmityl… (More)
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