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4'-hydroxydiazepam

Known as: 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-, 4-hydroxydiazepam, p-hydroxydiazepam 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

DiazepamTemazepam
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Impact of end-product inhibition on the determination of in vitro metabolic clearance
End-product inhibition was explored as a mechanism for the lower clearance determination obtained from microsomes compared with… 
2004
2004
Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes.
The diazepam (DZ)-omeprazole (OMP) interaction has been selected as a prototype for an important drug-drug interaction involving… 
1995
1995
Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance.
1. The rates of diazepam (DZ) metabolism to the primary metabolites 3-hydroxydiazepam, 4'-hydroxydiazepam and nordiazepam were… 
1990
1990
[Diazepam metabolism by multiple forms of cytochrome P-450 in rat liver microsomes].
The synthesis of pharmacologically active diazepam metabolites (oxazepam, 4-hydroxydiazepam, N-demethyldiazepam) in liver… 
1987
1987
Determination of diazepam and its metabolites by high-performance liquid chromatography and thin-layer chromatography.
1986
1986
Potencies of diazepam metabolites in rats trained to discriminate diazepam.
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