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4,5,6,7-tetrabromobenzimidazole

Known as: TBBZ cpd 
 
National Institutes of Health

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Broader (1)

Benzimidazoles

Papers overview

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2013
2013
Inhibition of protein kinase CK2 reduces Cyp24a1 expression and enhances 1,25-dihydroxyvitamin D(3) antitumor activity in human prostate cancer cells.
Vitamin D has broad range of physiological functions and antitumor effects. 24-Hydroxylase, encoded by the CYP24A1 gene, is the… Expand
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2013
2013
Inhibition of Protein Kinase CK 2 Reduces Cyp 24 a 1 Expression and Enhances 1 , 25-Dihydroxyvitamin D 3 Antitumor Activity in Human Prostate Cancer Cells
Vitamin D has broad range of physiological functions and antitumor effects. 24-Hydroxylase, encoded by the CYP24A1 gene, is the… Expand
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2012
2012
Modified tetrahalogenated benzimidazoles with CK2 inhibitory activity are active against human prostate cancer cells LNCaP in vitro.
A series of novel CK2 inhibitors, tetrahalogenated benzimidazoles carrying an aminoalkylamino group at position 2, has been… Expand
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2011
2011
Abstract 942: Protein kinase CK2 contributes to 1, 25-dihydroxyvitamin D3-mediated CYP24A1 gene expression in prostate cancer cells
The active vitamin D metabolite 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) plays a major role in regulating calcium homeostasis… Expand
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2010
2010
Synthesis and proapoptotic properties of new casein kinase II inhibitors.
Casein kinase II (CK2) is the most pleiotropic of all protein kinases with more than 300 substrates implicated in a wide variety… Expand
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2009
2009
Anti-Pentatrichomonas hominis activity of newly synthesized benzimidazole derivatives — in vitro studies
Pentatrichomonas hominis, a parasitic protozoan often detected in human diarrheic stools, is the cause of severe morbidity in… Expand
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2008
2008
New inhibitors of protein kinase CK2, analogues of benzimidazole and benzotriazole
Derivatives of 4,5,6,7-tetrabromobenzotriazole (TBBt) and 4,5,6,7-tetrabromobenzimidazole (TBBi) with IC50 in the low micromolar… Expand
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Highly Cited
2004
Highly Cited
2004
Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.
Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive… Expand
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2003
2003
Selectivity of 4,5,6,7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources.
Like the previously reported 4,5,6,7-tetrabromobenzotriazole (TBBt), the structurally related 4,5,6,7-tetrabromobenzimidazole… Expand
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2003
2003
Polyhalogenobenzimidazoles: synthesis and their inhibitory activity against casein kinases.
A series of novel polyhalogenated benzimidazoles have been prepared by exhaustive bromination of a variety of 2-substituted… Expand
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