4'-azidoadenosine

National Institutes of Health

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Highly Cited

2007

Highly Cited

2007

First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus.

Plinio Perrone, F. Daverio, C. Mcguigan
Journal of medicinal chemistry
2007
Corpus ID: 30478349

We report on the synthesis of the anti hepatitis C virus (HCV) agent 4'-azidoadenosine (1) and the application of the…