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3p22.3

A chromosome band present on 3p.
National Institutes of Health

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Chromosomes

Papers overview

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Highly Cited
2014
Highly Cited
2014
A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth
Deletion of 3p12-22 is frequent in multiple cancer types, indicating the presence of critical tumor-suppressor genes (TSGs) at… 
Highly Cited
2012
Highly Cited
2012
Loss of SNAIL regulated miR-128-2 on chromosome 3p22.3 targets multiple stem cell factors to promote transformation of mammary epithelial cells.
A discontinuous pattern of LOH at chromosome 3p has been reported in 87% of primary breast cancers. Despite the identification of… 
2012
2012
Loss of heterozygosity and methylation of multiple tumor suppressor genes on chromosome 3 in hepatocellular carcinoma
BackgroundGenetic and epigenetic alterations are the two key mechanisms in the development of hepatocellular carcinoma (HCC… 
Highly Cited
2011
Highly Cited
2011
A complete deficiency of Hyaluronoglucosaminidase 1 (HYAL1) presenting as familial juvenile idiopathic arthritis
We describe a single consanguineous family with three affected children exhibiting knee and/or hip pain associated with swelling… 
2010
2010
Aberrant promoter methylation of DLEC1, a critical 3p22 tumor suppressor for renal cell carcinoma, is associated with more advanced tumor stage.
Highly Cited
2009
Highly Cited
2009
Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer
Located at the important tumor suppressor locus, 3p22, PLCD1 encodes an enzyme that mediates regulatory signaling of energy… 
Highly Cited
2006
Highly Cited
2006
Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone hypoacetylation in human epithelial ovarian cancer.
Suppression of ovarian tumor growth by chromosome 3p was demonstrated in a previous study. Deleted in Lung and Esophageal Cancer… 
Highly Cited
2005
Highly Cited
2005
High‐resolution detection and mapping of genomic DNA alterations in neuroblastoma
We used array‐based comparative genomic hybridization (aCGH) to measure genomic copy number alterations (CNAs) in 42… 
2005
2005
Molecular analysis of a constitutional complex genome rearrangement with 11 breakpoints involving chromosomes 3, 11, 12, and 21 and a approximately 0.5-Mb submicroscopic deletion in a patient with…
Complex chromosome rearrangements (CCRs) are extremely rare but often associated with mental retardation, congenital anomalies… 
2003
2003
Differential deletions of chromosome 3p are associated with the development of uterine cervical carcinoma in Indian patients
Background: Deletions in chromosome 3 occur frequently in uterine cervical carcinoma (CA-CX). The common consensus regions… 
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