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3-hydroxypyridin-4-one

Known as: HP-4-one 
National Institutes of Health

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1 relation

Broader (1)

Pyridines

Papers overview

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2019
2019
DIBI, a novel 3-hydroxypyridin-4-one chelator iron-binding polymer, inhibits breast cancer cell growth and functions as a chemosensitizer by promoting S-phase DNA damage
Breast cancer is a leading cause of cancer-related death in women; however, chemotherapy of breast cancer is often hindered by… 
2012
2012
Prediction of 3-hydroxypyridin-4-one (HPO) hydroxyl pKa values.
As an aid in optimising the design of 3-hydroxypyridin-4-ones (HPOs) intended for use as therapeutic Fe(3+) chelating agents… 
2012
2012
Prediction of 3-hydroxypyridin-4-one (HPO) log K1 values for Fe(III).
As a means to aid in the design of 3-hydroxypyridin-4-ones (HPOs) intended for use as therapeutic Fe(3+) chelating agents, a… 
2009
2009
The selective quantification of iron by hexadentate fluorescent probes.
2008
2008
Synthesis and iron(III)-chelating properties of novel 3-hydroxypyridin-4-one hexadentate ligand-containing copolymers.
Iron overload is a critical clinical problem that can be prevented by the use of iron-specific chelating agents. An alternative… 
2002
2002
Synthesis and physicochemical assessment of novel 2‐substituted 3‐hydroxypyridin‐4‐ones, novel iron chelators
Novel 3‐hydroxypyridin‐4‐one containing tridentate ligands were synthesised and their physicochemical properties characterised… 
2001
2001
Structure-Function Investigation of the Interaction of 1- and 2-Substituted 3-Hydroxypyridin-4-ones with 5-Lipoxygenase and Ribonucleotide Reductase*
The structural and physiochemical properties of 3-hydroxypyridin-4-one chelators (HPOs) which influence inhibition of the iron… 
1994
1994
Copper complexation by 3-hydroxypyridin-4-one iron chelators: structural and iron competition studies.
Clinical trials of 1,2-dimethyl-3-hydroxypyridine-4-one (1) as an orally available iron chelator are presently underway in… 
1993
1993
In vivo and in vitro effects of 3-hydroxypyridin-4-one chelators on murine hemopoiesis.
The effects of 3-hydroxypyridin-4-one (HPO) iron chelators and desferrioxamine (DFO) on murine hemopoiesis in vivo and in vitro… 
Highly Cited
1991
Highly Cited
1991
The effect of N-alkyl modification on the antimalarial activity of 3-hydroxypyridin-4-one oral iron chelators.
The antimalaria effect of iron chelators is attributed to their interaction with a labile iron pool within parasitised… 
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