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3-hydroxypyridin-4-one

Known as: HP-4-one 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Pyridines

Papers overview

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2018
2018
DIBI, a 3-hydroxypyridin-4-one chelator iron-binding polymer with enhanced antimicrobial activity.
Depriving microorganisms of bioavailable iron is a promising strategy for new anti-infective agents. The new, highly water… 
2012
2012
Prediction of 3-hydroxypyridin-4-one (HPO) hydroxyl pKa values.
As an aid in optimising the design of 3-hydroxypyridin-4-ones (HPOs) intended for use as therapeutic Fe(3+) chelating agents… 
2008
2008
Synthesis and iron(III)-chelating properties of novel 3-hydroxypyridin-4-one hexadentate ligand-containing copolymers.
Iron overload is a critical clinical problem that can be prevented by the use of iron-specific chelating agents. An alternative… 
2001
2001
Structure-Function Investigation of the Interaction of 1- and 2-Substituted 3-Hydroxypyridin-4-ones with 5-Lipoxygenase and Ribonucleotide Reductase*
The structural and physiochemical properties of 3-hydroxypyridin-4-one chelators (HPOs) which influence inhibition of the iron… 
1994
1994
Copper complexation by 3-hydroxypyridin-4-one iron chelators: structural and iron competition studies.
Clinical trials of 1,2-dimethyl-3-hydroxypyridine-4-one (1) as an orally available iron chelator are presently underway in… 
1993
1993
In vivo and in vitro effects of 3-hydroxypyridin-4-one chelators on murine hemopoiesis.
The effects of 3-hydroxypyridin-4-one (HPO) iron chelators and desferrioxamine (DFO) on murine hemopoiesis in vivo and in vitro… 
Highly Cited
1992
Highly Cited
1992
Cell cycle synchronization and growth inhibition by 3-hydroxypyridin-4-one iron chelators in leukemia cell lines.
The effect of bidentate 3-hydroxypyridin-4-one (HPO) iron chelators on cell cycle arrest with subsequent cycle synchronization… 
Highly Cited
1991
Highly Cited
1991
Comparison of the subacute toxicity and efficacy of 3-hydroxypyridin-4-one iron chelators in overloaded and nonoverloaded mice.
Five orally effective iron chelators of the 3-hydroxypyridin-4-one series have been administered intraperitoneally to iron… 
Highly Cited
1991
Highly Cited
1991
Iron mobilization from myocardial cells by 3-hydroxypyridin-4-one chelators: studies in rat heart cells in culture.
The ability of 3-hydroxypyridin-4-ones (CP), a family of bidentate orally effective iron chelators, to remove iron and to prevent… 
Highly Cited
1991
Highly Cited
1991
The effect of N-alkyl modification on the antimalarial activity of 3-hydroxypyridin-4-one oral iron chelators.
The antimalaria effect of iron chelators is attributed to their interaction with a labile iron pool within parasitised… 
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