3-hydroxycoumarin

In the present work the origin of highly varied acidity of hydroxycoumarins (pKa values) has been for the first time investigated… Expand

The structure-activity relationships of four hydroxycoumarins, two with the hydroxyl group on the aromatic ring of the molecule… Expand

Human cytochrome P450 (P450) enzymes metabolize a variety of endogenous and xenobiotic compounds, including steroids, drugs, and… Expand

For more than 40 years coumarin has been successfully used in the therapy of chronic venous insufficiency (CVI). The occurrence… Expand

A series of hydroxylated 3-hydroxycoumarins was synthesised by the reaction of 3-aryl-2-hydroxypropenoic derivatives with boron… Expand

Coumarin, a widely used fragrance ingredient, is a rat liver and mouse lung toxicant. Species differences in toxicity are… Expand

o-Hydroxyphenylacetaldehyde (o-HPA), the product of coumarin 3, 4-epoxide, was synthesized and its contribution to the… Expand

1. o-Hydroxyphenylacetaldehyde was the major metabolite of coumarin (1 mM) in rat, gerbil and human liver microsomes. 2… Expand

1. The metabolism of [3-14C]coumarin has been studied in rat hepatic microsomes and with two purified cytochrome P-450 isoenzymes… Expand