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3,5-difluorotyrosine

Known as: Tyrosine, 3,5-difluoro, difluorotyrosine 
 
National Institutes of Health

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2 relations

Broader (1)

Tyrosine
analogs & derivatives

Papers overview

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2017
2017
Formal Reduction Potentials of Difluorotyrosine and Trifluorotyrosine Protein Residues: Defining the Thermodynamics of Multistep Radical Transfer.
Redox-active tyrosines (Ys) play essential roles in enzymes involved in primary metabolism including energy transduction and… Expand
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2017
2017
Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase.
Escherichia coli class Ia ribonucleotide reductase (RNR) is composed of two subunits that form an active α2β2 complex. The… Expand
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2016
2016
A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes
Escherichia coli class Ia ribonucleotide reductase (RNR) converts ribonucleotides to deoxynucleotides. A diferric-tyrosyl radical… Expand
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2016
2016
A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes.
Escherichia coli class Ia ribonucleotide reductase (RNR) converts ribonucleotides to deoxynucleotides. A diferric-tyrosyl radical… Expand
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2015
2015
Fluorinated Aromatic Amino Acids Distinguish Cation-π Interactions from Membrane Insertion*
Background: Peripheral membrane proteins can interact with zwitterionic phospholipid headgroups or lipid tails. Results… Expand
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2014
2014
Nano-size uni-lamellar lipodisq improved in situ auto-phosphorylation analysis of E. coli tyrosine kinase using 19F nuclear magnetic resonance
Among many of biophysical methods, F NMR spectroscopy has emerged as a powerful tool for characterizing protein structure… Expand
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2013
2013
Formal reduction potential of 3,5-difluorotyrosine in a structured protein: insight into multistep radical transfer.
The reversible Y-O•/Y-OH redox properties of the α3Y model protein allow access to the electrochemical and thermodynamic… Expand
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2013
2013
A genetically encoded 19F NMR probe for tyrosine phosphorylation.
Tyrosine phosphorylation is a pivotal post-translational modification (PTM) which regulates enzymatic activity, protein… Expand
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2008
2008
Synthesis of 3,5-difluorotyrosine-containing peptides: application in substrate profiling of protein tyrosine phosphatases.
Fully protected 3,5-difluorotyrosine (F2Y), Fmoc-F2Y(tBu)-OH, is efficiently prepared by a chemoenzymatic process and… Expand
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2003
2003
The role of acidic dissociation of substrate's phenol group in the mechanism of tyrosine phenol-lyase.
pH dependencies of the main kinetic parameters for the reaction of tyrosine phenol-lyase (TPL) with L-tyrosine were studied… Expand
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