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27-hydroxycholesterol 7-alpha-monooxygenase activity

Known as: 27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating), 27-hydroxycholesterol 7-alpha-hydroxylase activity, 27-hydroxycholesterol 7alpha-monooxygenase activity 
Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol. [EC:, MetaCyc:… Expand
National Institutes of Health

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BACKGROUND & AIMS Cyp 7-/- mice lack a functional cholesterol 7alpha-hydroxylase enzyme and develop cholestasis before up… Expand