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27-hydroxycholesterol 7-alpha-monooxygenase activity
27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
, 27-hydroxycholesterol 7-alpha-hydroxylase activity
, 27-hydroxycholesterol 7alpha-monooxygenase activity
Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol. [EC:188.8.131.52, MetaCyc:184.108.40.206-RXN…
National Institutes of Health
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Cholesterol 7-hydroxylase knockout mouse: a model for monohydroxy bile acid-related neonatal cholestasis.
Corpus ID: 23751547
BACKGROUND & AIMS Cyp 7-/- mice lack a functional cholesterol 7alpha-hydroxylase enzyme and develop cholestasis before up…
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