2-5A-dependent ribonuclease

Known as: pppA(2'p5'A)n-dependent ribonuclease, endoribonuclease L, RNase L 
2-5A-dependent ribonuclease (741 aa, ~84 kDa) is encoded by the human RNASEL gene. This protein plays a role in both RNA processing and the antiviral… (More)
National Institutes of Health

Papers overview

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2015
2015
OAS (2'-5'-oligoadenylate synthases) proteins and cyclic GMP-AMP synthase (cGAS, gene symbol: MB21D1) patrol the cytoplasm for… (More)
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2014
2014
OBJECTIVE This study aims to explore the clinical characteristics of ABCE1 in esophageal cancers and its roles in the… (More)
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2014
2014
RNase L is a cellular endoribonuclease that is activated by 2',5'-linked oligoadenylates (2-5A), which are unique and specific… (More)
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2013
2013
The latent ribonuclease RNase L and the interferon-inducible 2',5'-oligoadenylate synthetase (OAS) have been implicated in the… (More)
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2012
2012
2',5'-linked oligoadenylates (2-5As) serve as conserved messengers of pathogen presence in the mammalian innate immune system. 2… (More)
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2011
2011
Deadenylation is often the rate-limiting event in regulating the turnover of cellular mRNAs in eukaryotes. Removal of the poly(A… (More)
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2007
2007
RNase L is an antiviral endoribonuclease that cleaves viral mRNAs after single-stranded UA and UU dinucleotides. Poliovirus (PV… (More)
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Highly Cited
2006
Highly Cited
2006
Alleles at the Flv locus determine disease outcome after a flavivirus infection in mice. Although comparable numbers of congenic… (More)
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2002
2002
We previously showed that the intrahepatic induction of cytokines such as alpha/beta interferon (IFN-alpha/beta) and gamma… (More)
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1997
1997
Expression of low levels of the 2',5'-linked oligoadenylate-dependent human RNase L, an enzyme induced by interferons, is highly… (More)
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