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2-5A-dependent ribonuclease

Known as: pppA(2'p5'A)n-dependent ribonuclease, endoribonuclease L, RNase L 
2-5A-dependent ribonuclease (741 aa, ~84 kDa) is encoded by the human RNASEL gene. This protein plays a role in both RNA processing and the antiviral… Expand
National Institutes of Health

Related topics

Related topics

14 relations
Ankyrin RepeatAntiviral ResponseCytoplasmic matrixEnzyme Gene
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Broader (1)

Endoribonucleases

Papers overview

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2017
2017
Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.
Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated ribonuclease H (RNase H) remains the only virally… Expand
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2015
2015
Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome
Significance The mammalian innate immune system recognizes double-stranded RNA (dsRNA) as a signature of infections and cell… Expand
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2015
2015
RNase L Cleavage Products Promote Switch from Autophagy to Apoptosis by Caspase-Mediated Cleavage of Beclin-1
Autophagy and apoptosis share regulatory molecules enabling crosstalk in pathways that affect cellular homeostasis including… Expand
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2014
2014
RNase L Interacts with Filamin A To Regulate Actin Dynamics and Barrier Function for Viral Entry
ABSTRACT The actin cytoskeleton and its network of associated proteins constitute a physical barrier that viruses must circumvent… Expand
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2013
2013
The ribonuclease l‐dependent antiviral roles of human 2′,5′‐oligoadenylate synthetase family members against hepatitis C virus
The latent ribonuclease RNase L and the interferon‐inducible 2′,5′‐oligoadenylate synthetase (OAS) have been implicated in the… Expand
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2012
2012
Innate immune messenger 2-5A tethers human RNase L into active high-order complexes.
2',5'-linked oligoadenylates (2-5As) serve as conserved messengers of pathogen presence in the mammalian innate immune system. 2… Expand
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Highly Cited
2007
Highly Cited
2007
A Phylogenetically Conserved RNA Structure in the Poliovirus Open Reading Frame Inhibits the Antiviral Endoribonuclease RNase L
ABSTRACT RNase L is an antiviral endoribonuclease that cleaves viral mRNAs after single-stranded UA and UU dinucleotides… Expand
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Highly Cited
2006
Highly Cited
2006
RNase L Plays a Role in the Antiviral Response to West Nile Virus
ABSTRACT Alleles at the Flv locus determine disease outcome after a flavivirus infection in mice. Although comparable numbers of… Expand
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Highly Cited
2002
Highly Cited
2002
Interferon-Regulated Pathways That Control Hepatitis B Virus Replication in Transgenic Mice
ABSTRACT We previously showed that the intrahepatic induction of cytokines such as alpha/beta interferon (IFN-α/β) and gamma… Expand
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Highly Cited
1972
Highly Cited
1972
Reactivation of des (119-124) ribonuclease A by mixture with synthetic COOH-terminal peptides; the role of phenylalanine-120.
Abstract Several peptides contained within the amino acid sequence -Glu-Gly-Asn-Pro-Tyr-Val-Pro-Val-His-Phe-Asp-Ala-Ser-Val-OH at… Expand
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