2-5A-dependent ribonuclease

Known as: pppA(2'p5'A)n-dependent ribonuclease, endoribonuclease L, RNase L 
2-5A-dependent ribonuclease (741 aa, ~84 kDa) is encoded by the human RNASEL gene. This protein plays a role in both RNA processing and the antiviral… (More)
National Institutes of Health

Related topics

Related topics

14 relations
Ankyrin RepeatAntiviral ResponseCytoplasmic matrixEnzyme Gene
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Broader (1)

Endoribonucleases

Papers overview

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2015
2015
OASes and STING: Adaptive Evolution in Concert
OAS (2'-5'-oligoadenylate synthases) proteins and cyclic GMP-AMP synthase (cGAS, gene symbol: MB21D1) patrol the cytoplasm for… (More)
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2014
2014
Depleting ABCE1 expression induces apoptosis and inhibits the ability of proliferation and migration of human esophageal carcinoma cells.
OBJECTIVE This study aims to explore the clinical characteristics of ABCE1 in esophageal cancers and its roles in the… (More)
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2014
2014
Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L.
RNase L is a cellular endoribonuclease that is activated by 2',5'-linked oligoadenylates (2-5A), which are unique and specific… (More)
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2013
2013
The ribonuclease L-dependent antiviral roles of human 2',5'-oligoadenylate synthetase family members against hepatitis C virus.
The latent ribonuclease RNase L and the interferon-inducible 2',5'-oligoadenylate synthetase (OAS) have been implicated in the… (More)
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2012
2012
Innate immune messenger 2-5A tethers human RNase L into active high-order complexes.
2',5'-linked oligoadenylates (2-5As) serve as conserved messengers of pathogen presence in the mammalian innate immune system. 2… (More)
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2011
2011
PolyA-specific ribonuclease (PARN-1) function in stage-specific mRNA turnover in Trypanosoma brucei.
Deadenylation is often the rate-limiting event in regulating the turnover of cellular mRNAs in eukaryotes. Removal of the poly(A… (More)
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2007
2007
A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
RNase L is an antiviral endoribonuclease that cleaves viral mRNAs after single-stranded UA and UU dinucleotides. Poliovirus (PV… (More)
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Highly Cited
2006
Highly Cited
2006
RNase L plays a role in the antiviral response to West Nile virus.
Alleles at the Flv locus determine disease outcome after a flavivirus infection in mice. Although comparable numbers of congenic… (More)
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2002
2002
Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice.
We previously showed that the intrahepatic induction of cytokines such as alpha/beta interferon (IFN-alpha/beta) and gamma… (More)
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1997
1997
Growth of Escherichia coli in acetate as a sole carbon source is inhibited by ankyrin-like repeats present in the 2',5'-linked oligoadenylate-dependent human RNase L enzyme.
Expression of low levels of the 2',5'-linked oligoadenylate-dependent human RNase L, an enzyme induced by interferons, is highly… (More)
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