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2'-deoxyzebularine

National Institutes of Health

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2 relations

Broader (1)

Cytidine
analogs & derivatives

Papers overview

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2019
2019
Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues
APOBEC3 enzymes form part of the innate immune system by deaminating cytosine to uracil in single-stranded DNA (ssDNA) and… 
2019
2019
Selective inhibition of APOBEC3 enzymes by single-stranded DNAs containing 2'-deoxyzebularine.
To restrict pathogens, in a normal human cell, APOBEC3 enzymes mutate cytosine to uracil in foreign single-stranded DNAs. However… 
2019
2019
Differential Inhibition of APOBEC3 DNA‐Mutator Isozymes by Fluoro‐ and Non‐Fluoro‐Substituted 2′‐Deoxyzebularine Embedded in Single‐Stranded DNA
The APOBEC3 (APOBEC3A‐H) enzyme family is part of the human innate immune system that restricts pathogens by scrambling… 
2014
2014
Efficient synthesis of 2'-deoxyzebularine and its α-anomer by the silyl method of N-glycosylation. Crystal structures and conformational study in solution.
2009
2009
Synthesis and Hybridization Properties of Modified Oligodeoxynucleotides Carrying Non‐Natural Bases
The impact of the presence of nonnatural bases on the properties of oligodeoxynucleotides has been studied. First… 
2008
2008
Activation of p16 gene silenced by DNA methylation in cancer cells by phosphoramidate derivatives of 2'-deoxyzebularine.
We report herein the application of the phosphoramidate ProTide technology to improve the metabolism of the DNA methytransferase… 
2004
2004
Synthesis, stability, and protonation studies of a self‐complementary dodecamer containing the modified nucleoside 2′‐deoxyzebularine
The nucleoside 2′‐deoxyzebularine (K) was incorporated into the self‐complementary dodecamer 5′‐CGTACGKGTACG‐3′ by solid‐phase 2… 
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