1,3-diaza-2-oxophenothiazine

 
National Institutes of Health

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2015
2015
Fluorescent Sensor for PH Monitoring Based on ani-Motif- – Switching Aptamer Containing a Tricyclic Cytosine Analogue (tC)
There are cytosine-rich regions in the genome that bind protons with high specificity. Thus protonated C-rich sequence may… (More)
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2013
2013
Discrimination against major groove adducts by Y-family polymerases of the DinB subfamily.
Y-family DNA polymerases bypass DNA adducts in a process known as translesion synthesis (TLS). Y-family polymerases make contacts… (More)
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2011
2011
Discrimination against the cytosine analog tC by Escherichia coli DNA polymerase IV DinB.
The cytosine analog 1,3-diaza-2-oxophenothiazine (tC) is a fluorescent nucleotide that forms Watson-Crick base pairs with dG. The… (More)
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2011
2011
Effect of transition metal ions on the fluorescence and Taq-catalyzed polymerase chain reaction of tricyclic cytidine analogs.
The cytosine analogs 1,3-diaza-2-oxophenothiazine (tC) and 1,3-diaza-2-oxophenoxazine (tCo) stand out among fluorescent bases due… (More)
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2010
2010
Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate.
Human DNA primase synthesizes short RNA primers that DNA polymerase alpha then elongates during the initiation of all new DNA… (More)
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2009
2009
Ambivalent incorporation of the fluorescent cytosine analogues tC and tCo by human DNA polymerase alpha and Klenow fragment.
We studied the incorporation of the fluorescent cytidine analogues 1,3-diaza-2-oxophenothiazine (tC) and 1,3-diaza-2… (More)
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2009
2009
Synthesis of a fluorescent 2'3'-dideoxycytosine analog, tCdd.
The pathway leading to the preparation of a novel tricyclic 2'3'-dideoxycytosine analog, tCdd (1) is reported. A protected 2'3… (More)
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2009
2009
Fluorophore-quencher pair for monitoring protein motion.
A fluorophore/quencher pair capable of detecting conformational changes of DNA-protein complexes is described. The system employs… (More)
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2007
2007
Conformational dynamics of DNA polymerase probed with a novel fluorescent DNA base analogue.
DNA polymerases discriminate between correct and incorrect nucleotide substrates during a "nonchemical" step that precedes… (More)
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2005
2005
Fluorescent properties of DNA base analogue tC upon incorporation into DNA — negligible influence of neighbouring bases on fluorescence quantum yield
The quantum yield of the fluorescent tricyclic cytosine analogue, 1,3-diaza-2-oxophenothiazine, tC, is high and virtually… (More)
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