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[tyrosine 3-monooxygenase] kinase activity

Known as: STK4, pheochromocytoma tyrosine hydroxylase-associated kinase activity, tyrosine 3-monooxygenase kinase (phosphorylating) activity 
Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]. [EC:2.7.11.6, MetaCyc:TYROSINE-3… Expand
National Institutes of Health

Papers overview

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2019
2019
B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects.
Humoral immune defects are described in 9 patients from 5 families with STK4 deficiency. A mouse model carrying the novel p… Expand
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2019
2019
Suppression of long non‐coding RNA TNRC6C‐AS1 protects against thyroid carcinoma through DNA demethylation of STK4 via the Hippo signalling pathway
Abstract Objectives Thyroid carcinoma (TC) represents a malignant neoplasm affecting the thyroid. Current treatment strategies… Expand
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2015
2015
STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is frequently associated with pathogen infection-induced chronic inflammation. Large numbers of… Expand
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2015
2015
LC3 is a novel substrate for the mammalian Hippo kinases, STK3/STK4
The Atg8 family protein LC3 is indispensible for autophagy and plays critical roles in multiple steps of the process. Despite… Expand
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Highly Cited
2014
Highly Cited
2014
RESCUE OF HIPPO CO-ACTIVATOR YAP1 TRIGGERS DNA DAMAGE-INDUCED APOPTOSIS IN HEMATOLOGICAL CANCERS
Oncogene-induced DNA damage elicits genomic instability in epithelial cancer cells, but apoptosis is blocked through inactivation… Expand
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Highly Cited
2014
Highly Cited
2014
MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo
MicroRNAs (miRNAs) comprise a class of short, non-coding RNAs that regulate protein synthesis through posttranscriptional… Expand
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2014
2014
An alternative DNA damage pathway to apoptosis in hematological cancers
Although hematological cancers are genomically unstable, the mechanisms by which they evade DNA damage–induced cell death are… Expand
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2013
2013
Abstract 1146: STK4 downregulation promotes tumor invasion/migration and is associated with poor prognosis in human colon cancer.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Colon cancer has high incidence rate in the world… Expand
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2011
2011
Using biomedical networks to prioritize gene–disease associations
correspondence: Joel Perdiz Arrais University of Aveiro, 3810-193 Aveiro, Portugal Tel +35 1234370500 Fax +35 1234370545 email… Expand
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1999
1999
Catalytic Mechanism of 2-Hydroxybiphenyl 3-Monooxygenase, a Flavoprotein from Pseudomonas azelaica HBP1*
2-Hydroxybiphenyl 3-monooxygenase (EC1.14.13.44) from Pseudomonas azelaica HBP1 is an FAD-dependent aromatic hydroxylase that… Expand
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