Transactions on Materials, Biotechnology and Life…
11 October 2025
Herpes simplex virus type 2 (HSV-2) is a globally prevalent sexually transmitted infection, affecting an estimated 491 million people worldwide. The virus establishes lifelong latency in the sensory…
ABSTRACT A defining characteristic of alphaherpesviruses is the establishment of lifelong latency in host sensory ganglia with occasional reactivation causing recurrent lytic infections. As an…
We describe a primary neuronal culture system suitable for molecular characterization of herpes simplex virus type 1 (HSV-1) infection, latency, and reactivation. While several alternative models are…
ABSTRACT Herpes simplex virus type 1 (HSV-1) and HSV-2 cause very similar acute infections but differ in their abilities to reactivate from trigeminal and dorsal root ganglia. To investigate…
ABSTRACT Using real-time fluorescence PCR, we quantitated the numbers of copies of latent varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) genomes in 15 human…
BackgroundTherapeutic vaccines can be designed to enhance existing T cell memory populations for increased protection against re-infection. In the case of herpes simplex virus type 1, recurrent…
A hallmark of herpes viruses is their capacity to cause recurrent disease. Recurrences of herpes simplex virus (HSV)-1 disease do not result from reinfection from external sources, but rather from…
ABSTRACT The replication properties of a thymidine kinase-negative (TK−) mutant of herpes simplex virus type 1 (HSV-1) were exploited to examine the relative contributions of replication at the body…
Our current understanding of HSV latency is based on a variety of clinical observations, and in vivo, ex vivo, and in vitro model systems, each with unique advantages and drawbacks. The criteria for…