Tspyl2 Loss-of-Function Causes Neurodevelopmental Brain and Behavior Abnormalities in Mice

@article{Li2016Tspyl2LC,
  title={Tspyl2 Loss-of-Function Causes Neurodevelopmental Brain and Behavior Abnormalities in Mice},
  author={Qi Li and Siu Yuen Chan and Kwun Kiu Wong and Ran Wei and Yu On Leung and Abby Ding and Tomy C. K. Hui and Charlton Cheung and Siew E. Chua and Pak Chung Sham and Ed X. Wu and Gr{\'a}inne M. McAlonan},
  journal={Behavior Genetics},
  year={2016},
  volume={46},
  pages={529 - 537},
  url={https://api.semanticscholar.org/CorpusID:2934014}
}
It is suggested that disrupting Tspyl2 gene expression leads to behavioral and brain morphological alterations that mirror a number of neurodevelopmental psychiatric traits.
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13 Citations

TSPYL2 Regulates the Expression of EZH2 Target Genes in Neurons

ChIP showed that hemagglutinin-tagged TSPYL2 co-existed with EZH2 in target promoters in neuroblastoma cells, and suggested that TSPyl2 is recruited to promoters of specific EZh2 target genes in neurons, and enhances their expression for proper neuronal maturation and function.

Title TSPYL 2 regulates the expression of EZH 2 target genes inneurons

ChIP showed that hemagglutinin-tagged TSPYL2 co-existed with EZH2 in target promoters in neuroblastoma cells, and suggested that TSPyl2 is recruited to promoters of specific EZh2 target genes in neurons, and enhances their expression for proper neuronal maturation and function.

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Abstract The gonadoblastoma gene, testis‐specific protein Y‐encoded (TSPY), on the Y chromosome and its X‐homologue, TSPX, are cell cycle regulators and function as a proto‐oncogene and a tumor…

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62 References

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Robust and selective social deficits, repetitive self‐grooming, genetic stability and commercial availability of the BTBR inbred strain encourage its use as a research tool to search for background genes relevant to the etiology of autism, and to explore therapeutics to treat the core symptoms.

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