Thrombosis in adult patients with acute leukemia
@article{delPrincipe2017ThrombosisIA, title={Thrombosis in adult patients with acute leukemia}, author={Maria Ilaria del Principe and Domenico Del Principe and Adriano Venditti}, journal={Current Opinion in Oncology}, year={2017}, volume={29}, pages={448–454}, url={https://api.semanticscholar.org/CorpusID:32987521} }
Thrombosis represents a serious complication in patients affected by myeloid and lymphoid acute leukemia and a proper knowledge of its pathophysiology and of the predisposing risk factors may allow to implement strategies of prevention.
38 Citations
Thrombosis in Acute Myeloid Leukemia: Pathogenesis, Risk Factors and Therapeutic Challenges
- 2023
Medicine
A greater effort should be made to identify robust predictive factors able to guide clinicians in the management of this potential serious complication for AML patients, and some of the unanswered questions that the future guidelines and trials should address.
Thrombosis in Acute Promyelocytic Leukemia: The Current Understanding
- 2023
Medicine
A detailed analysis of thrombotic risks in APL with the development of a reliable risk stratification model is needed to further improve the care of APL patients.
Arterial Thrombosis in Patients with Acute Myeloid Leukemia: Incidence and Risk Factors
- 2023
Medicine
The study showed that patients with AML are at increased risk of ATE, and the risk was increased in patients with cardiovascular comorbidities, previous thrombosis, adverse cytogenetic risk as well as BMI > 30.
Management of Disseminated Intravascular Coagulation in Acute Leukemias
- 2021
Medicine
The cornerstone of managing DIC is the treatment of the underlying disease, as exemplified by the important role of early administration of all-trans retinoic acid in APL.
A case of acute myelogenous leukemia characterized by arterial and venous thrombosis.
- 2020
Medicine
An unusual case of anti-phospholipid antibody syndrome secondary to AML characterized by venous and arterial thrombosis is reported, which is challenging to anticoagulated AML patients complicated by multiple vascularThromboses and thromBocytopenia.
Predictors of Early Thrombotic Events in Adult Patients with Acute Myeloid Leukemia: A Real-World Experience
- 2022
Medicine
An early-VTE risk score that could be useful for a proper management of VTE prophylaxis is proposed that may help in implementing strategies to manage patients at higher risk of early thrombotic complications.
The incidence and risk factors of thrombosis and the need for thromboprophylaxis in lymphoma and leukemia patients: A 9-year single-center experience
- 2019
Medicine
Acute leukemia patients with any comorbidity and lymphoma patients with higher lactate dehydrogenase and beta-2-microglobulin levels are at high risk of developing thromboembolic complications and the prophylactic use of anticoagulant should be considered for those patients especially in the first 6 months.
Frequency and risk factors for thrombosis in acute myeloid leukemia and high-risk myelodysplastic syndromes treated with intensive chemotherapy: a two centers observational study
- 2022
Medicine
Previous VTE, platelet count above 100 × 109/L and active smoking were the only factors associate with increased thrombotic risk in AML patients treated intensively, but further studies are needed to validate these results.
Simplified predictive scores for thrombosis and bleeding complications in newly diagnosed acute leukemia patients
- 2023
Medicine
The proposed Siriraj Acute Myeloid/Lymphoblastic Leukemia (SiAML) bleeding and thrombosis scoring system might be valuable for prognosticating individuals at risk for bleeding and thrombotic complications and Prospective validation studies are needed to verify its usefulness.
112 References
Incidence of thrombosis in adults with acute leukemia: a single center experience in Mexico.
- 2013
Medicine
The incidence of thrombosis in this adult acute leukemia population is comparable to that reported in the literature and Prospective studies are necessary in order to assess the risk factors fostering thromBosis in adult patients with acute leukemia.
The risk of thrombosis in patients with acute leukemia: occurrence of thrombosis at diagnosis and during treatment
- 2005
Medicine
In patients with acute leukemia, the risk of thrombosis is not negligible, but is significantly increased by further treatment up to 10.6%.
Thrombosis in Leukemia: Incidence, Causes, and Practical Management
- 2015
Medicine
Treatment relies in the use of heparin, followed by vitamin K antagonists for 3 to 6 months, however, randomized controlled studies are required in patients with AL and thrombosis to confirm its safety, duration, and effectiveness.
Disseminated intravascular coagulation at diagnosis is a strong predictor for thrombosis in acute myeloid leukemia.
- 2016
Medicine
It is concluded that venous and arterial thrombosis may develop in ∼10% of AML patients treated with intensive chemotherapy, which to a large extent can be predicted by the presence of DIC at time ofAML diagnosis.
Symptomatic venous thromboembolism in acute leukemia. Incidence, risk factors, and impact on prognosis.
- 2005
Medicine
Venous thromboembolism in patients with acute leukemia: incidence, risk factors, and effect on survival.
- 2009
Medicine
The incidence of VTE in acute leukemia is appreciable, and is comparable with the incidence in many solid tumors, and the risk factors for VTE were presence of a central venous catheter, older age, and number of chronic comorbidities.
Occurrence of thrombotic events in acute promyelocytic leukemia correlates with consistent immunophenotypic and molecular features
- 2007
Medicine
In APL patients consistent biologic features of leukemia cells may predict increased risk of developing thrombosis, according to clinico-biologic characteristics of patients with and without thromBosis.