The radiosensitivity of germ-cells at various stages of ovarian development.

@article{Beaumont1962TheRO,
  title={The radiosensitivity of germ-cells at various stages of ovarian development.},
  author={Heather M. Beaumont},
  journal={International journal of radiation biology and related studies in physics, chemistry, and medicine},
  year={1962},
  volume={4},
  pages={
          581-90
        },
  url={https://api.semanticscholar.org/CorpusID:35334454}
}
As judged by the survival of oocytes at the age of 25 days, germ-cells in the developing ovary undergo two periods of high radiosensitivity: the first at 15 days post coitum, when oogonial mitoses are frequent, and the second shortly after birth, when the oocytes attain the dictyate phase.

The radiosensitivity of oögonia and oöcytes in the chick embryo

Oocytes at the leptotene, zygotene and pachytene stages are relatively radioresistant and Corresponding observations on oogonia and oocytes of the developing avian embryo are scanty, and some were made before the advent of accurate dosimetry.

THE RADIOSENSITIVITY OF GERM CELLS

The yield of mutations observed after irradiation of different developmental stages may be at least partly determined by the selective elimination, during subsequent development, of cells sensitive to immediate or delayed cell‐death.

A study of the mitotically active germ cells of the gonads of x-irradiated chick embryos.

It is suggested that the sensitivity of germ cells in division is independent of the influence of sex and age, and the percentage of dividing cells increased within 24 hours after irradiation.

The age dependence of radiation sensitivity of the gonads of female mice.

Female CBA-mice were continuously gamma-irradiated with 0.9 or 2.4 Gy for an initial period of about 90 days followed by a period of fatal radiation effects, suggesting a changing radiation sensitivity by age during an initial Period of About 90 days.

Comparative aspects of the effects of radiation during oogenesis.

    T. G. Baker
    Biology, Environmental Science
  • 1971

Radiosensitivity of oocytes in post-natal guinea-pigs.

Contracted oocytes were consistently and significantly more sensitive to irradiation, even over a short (3 days) post-irradiation interval, and over a longer interval (16 or 32 days) a dose-dependent response was revealed: the higher the dose, the smaller the number of surviving oocytes.

Effects of neonatal ovarian X-irradiation in the Chinese hamster. I. Correlation between the age of irradiation and the fertility span.

The present study indicated again that the sensitivity of the oocytes to the lethal effects of X-rays is unquestionably meiotic stage-dependent.

Effect of 90Sr on ovaries of foetal mice depending on time for administration during pregnancy.

    C. Rönnbäck
    Environmental Science, Medicine
  • 1979
The reduction of the number of cells in the ovaries was strongly correlated to the time of administration of the nuclide with a more increased effect the later during foetal development the contamination occurred.

Absence of late effects on survival and developmental abilities of pachytene oocytes X-irradiated during neonatal stages in the Chinese hamster.

It is indicated clearly that pachytene oocytes were not affected at all by either acute or late effects of X-rays although the dose was high enough to kill diplotene-dictyate oocytes completely.

EFFECTS OF X-IRRADIATION OF MICE EXPOSED IN UTERO DURING DIFFERENT STAGES OF EMBRYOLOGICAL DEVELOPMENT ON DURATION OF MATURE LIFE

1. Mature lifespans, 75 days of age to death, when the mice were exposed to irradiations at different stages of uterine development, showed reductions in mean longevity which were dependent on both
...

The effect of cysteamine on the survival of foetal germ cells after irradiation.

Pre-treatment of the pregnant rats with cysteamine shortly before irradiation partially inhibits the deleterious effect of irradiation on the testes of the offspring.

Changes in the radiosensitivity of the testis during foetal development.

A quantitative histological study of the testes showed that there was a curvilinear relationship between the proportion of seminiferous tubules classified as normal and sterile and the dose to which the animals had been exposed and foetal age at the time of exposure.

Radiosensitivity of male germ-cells in neonatal rats.

A quantitative histological study of the testes showed that there is a decrease in the radiosensitivity of male germ-cells between 1 and 4 days, which does not coincide with microscopically demonstrable signs of nuclear activity in the gonocytes.

A quantitative study of the sensitivity of oocytes to X-irradiation

    A. Mandl
    Biology
  • 1959
In a quantitative study of the reaction of the rat ovary to X-irradiation, a curvilinear relationship has been established between the number of oocytes that survives exposure to X -rays, and (i) the

The numbers of normal and atretic ova in the mature rat.

There is no consensus about the part played by the germinal epithelium in oogenesis, nor is it established beyond dispute that oocytes continue to be produced throughout the reproductive life of an animal, but general view is that the number of oocytes in an ovary varies systematically with the phases of the cycle.

The formation of the sex glands and germ cells of mammals. III. The history of the female germ cells in the albino rat to the time of sexual maturity

The entire ovary, including its germ cells, is produced by a local proliferation of peritoneal cells, which results in a normal maturation, then a degeneration of all the ova by about thirty‐two days after birth.

X-ray sensitivity of primary spermatocytes of the mouse.int.

There was an inverse relation between cell-killing and chromosome breakage: pre-leptotene was the most sensitive and diakinesis-metaphase I the most resistant to induction of cell death; whereas pre-Leptotenes and leptonotene were the mostresistant and metaphase IThe most sensitive to chromosomes breakage.

Histochemical observations on the germ cells of human embryos

Witschi (’48)’ in a scholarly treatment of the problem has presented sound morphologic evidence that, germ cells of the human arise from the endoderm of the yolk sac or from primitive stem cells which also are the source of theendoderm.

The identification, origin, and migration of the primordial germ cells in the mouse embryo

The extra-gonadal origin of the primordial germ cells and the existence of the so-called "I<eimbahn" or germ-tract is today accepted by most investigators, but in mammalian embryos the existence has been claimed by some and denied by others.

Book Review

This edition of Histochemistry: Theoretical and Applied contains many colour illustrations, helpful in understanding light and fluorescence microscopical tests, and colour diagrams that assist the beginner and scientists in other fields in understanding the subject.