The influence of perfusion solution on renal graft viability assessment

@article{Wilson2012TheIO,
  title={The influence of perfusion solution on renal graft viability assessment},
  author={Colin H. Wilson and Hugh Wyrley-Birch and Dhakshina Vijayanand and Anabelle Leea and Noel Carter and Malcolm Haswell and Anne Catherine Cunningham and David Talbot},
  journal={Transplantation Research},
  year={2012},
  volume={1},
  pages={18 - 18},
  url={https://api.semanticscholar.org/CorpusID:67917}
}
It is concluded that initial machine perfusion viability tests, including ischemic vascular resistance and GST, are dependent on the perfusion solution used during in situ cooling.
View on Springer
transplantationresearch.biomedcentral.com
4 Citations
Background Citations
1

4 Citations

Assessing Kidney Graft Viability and Its Cells Metabolism during Machine Perfusion

Current tools for graft viability assessment using machine perfusion prior to implantation in relation to the ischemic damage are summarized.

Efficacy of liver graft washout as a function of the perfusate, pressure, and temperature

No differences were found in portal washout efficacy between colloidal solutions, histidine tryptophan ketoglutarate, and RL and a single portal wash out with any of the solutions did not result in differences in the degree of RBC retention, regardless of the temperature or pressure.

Lesion por isquemia-reperfusión en donantes a corazon parado. Impacto sobre la evolución en el trasplante renal

La donacion no controlada tras muerte cardiaca (uDCD) en Espana proporciono uno de cada cuatro donantes en 2016, bien desarrollada en multitud of programas en nuestro pais.

SOLUÇÃO DE KREBS-HENSELEIT COMO AGENTE DE MANUTENÇÃO E CONSERVAÇÃO DE ÓRGÃOS: REVISÃO

A solução de Krebs-Henseleit (K-H) é um meio fisiológico fundamental na pesquisa experimental de preservação de órgãos, embora seu uso clínico direto em transplantes seja limitado. Esta revisão…

30 References

Comparative efficacy of renal preservation solutions to limit functional impairment after warm ischemic injury.

The data show that postischemic renal function can be influenced by the choice of preservation fluid, and, while HOC and UW solutions were better able to limit the decline in renal function after warm ischemia than EC, the solution most ability to limit functional impairment after warm waschemia was PBS140.

Evaluation of Eight Preservation Solutions for Endothelial in situ Preservation

In this model of ISP, HTK retained a powerful ability to preserve endothelial structure and function during warm ischemia, which requires a large volume of fluid to be pumped at high flow rates.

Comparison of HTK and hypertonic citrate to intraarterial cooling in human non-heart-beating kidney donors.

Warming to Non‐heart‐beating Donors?

Cold machine perfusion has helped to reduce delayed graft function and improve graft survival in non-heart-beating kidneys.

A pathophysiologic study of the kidney tubule to optimize organ preservation solutions.

A novel in vitro system to model cold and warm ischemic-induced renal tubule swelling that characterizes tissue damage in ischemia/reperfusion injury shows that the model could reproduce ischemically induced cell swelling and characterized the response at the cellular level of tubules to different components of preservation solutions.

Kidney Transplantation from a Donor Following Cardiac Death Supported with Extracorporeal Membrane Oxygenation

It is suggested that kidney transplantation from a category II DCD donor assisted by ECMO is a reasonable modality for expanding donor pool.

Use of two biomarkers of renal ischemia to assess machine-perfused non-heart-beating donor kidneys.

Original work by the Maastricht NHBD group has established threshold limits for tGST activity in kidney perfusates for the selection of “viable” kidneys for transplantation, and this criterion has been introduced in Newcastle, England, where 69 NHBD renal transplants have …

Kidney transplantation from organ donors following cardiopulmonary death using extracorporeal membrane oxygenation support.

Kidneys donated from "controlled" ECMO supported CPD donors are a viable source of organs for renal transplantation and this recovery method warrants further investigation.

Glutathione S-transferase as predictor of functional outcome in transplantation of machine-preserved non-heart-beating donor kidneys.

MP is useful in evaluating the viability of NHB donor kidneys, and the parameters discussed will help to select nonviable grafts from this valuable pool of kidneys for transplantation.

IN SITU PRESERVATION OF KIDNEYS FROM NON‐HEART-BEATING DONORS—A PROPOSAL FOR A STANDARDIZED PROTOCOL

A protocol for the emergency in situ preservation procedure that can be practiced in most hospitals is presented and resulted in 20% more kidneys available for transplantation at the University Hospital of Maastricht, The Netherlands.