Otosclerosis: a measles virus associated inflammatory disease.

@article{Niedermeyer1995OtosclerosisAM,
  title={Otosclerosis: a measles virus associated inflammatory disease.},
  author={Hans Peter Niedermeyer and Wolfgang Arnold},
  journal={Acta oto-laryngologica},
  year={1995},
  volume={115 2},
  pages={
          300-3
        },
  url={https://api.semanticscholar.org/CorpusID:28329241}
}
The results support the previously stated hypothesis that otosclerosis is a measles virus associated disease which provokes a local immune response within the inner ear.
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69 Citations
Highly Influential Citations
2
Background Citations
15
Methods Citations
5
Results Citations
2

69 Citations

Measles virus in otosclerosis and the specific immune response of the inner ear.

Measles virus specific antibodies were detected in all of the perilymph samples from 19 patients suffering from otosclerosis, and the relative amount of these IgG antibodies was much higher than in serum samples of the same patients or inperilymph of control patients.

Persistent Measles Virus Infection and Otosclerosis

The spontaneous form of otosclerosis is, in the vast majority of cases, a measles virus-associated disease of the otic capsule.

Measles virus prevalence in otosclerotic foci.

The presence of measles virus was shown in otosclerotic patients by RT-PCR amplification of the viral RNA, detecting the viral proteins by immunohistochemistry and antimeasles immunoglobulin G in the perilymph samples.

Measles Virus Prevalence in Otosclerotic Stapes Footplate Samples

The etiologic role of measles virus in the pathogenesis of otosclerosis should be considered and 14 negative samples may be genetically determined otosclerotic cases.

No Evidence for an Association between Persistent Measles Virus Infection and Otosclerosis among Patients with Otosclerosis in Japan

The hypothesis that persistent MV infection is involved in the pathoetiology of otosclerosis is not supported as the results do not support the hypothesis.

No Evidence of Measles Virus in Stapes Samples from Patients with Otosclerosis

These highly sensitive methods could not evidence the presence of the measles virus in any of the bone samples or primary bone cell cultures, and the hypothesis of persistent measles virus infection in otosclerosis is not confirmed.

Histologic Otosclerosis Is Associated with the Presence of Measles Virus in the Stapes Footplate

Stapes ankylosis is a heterogenous disease causing conductive hearing loss with different causes and nonotosclerotic stapes fixations may belong to degenerative disorders with variable histopathology.

Measles virus and otosclerosis.

A strong association between MeV and otosclerosis is confirmed and the presence of MeV genotype A, which circulated in Europe around 1960, is demonstrated.

Antimeasles Immunoglobulin G in Sera of Patients with Otosclerosis Is Lower than that in Healthy People

Background There is some evidence for an inflammatory process as a driving force in otosclerosis. Two popular hypotheses for the induction of this chronic inflammation have been proposed: an…

Restriction analysis of otosclerosis-associated CD46 splicing variants

Otosclerosis is a primary bone remodeling disorder of the human otic capsule and is associated with persistent measles virus infection. The human cellular receptor of measles virus is the membrane…
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19 References

[Otosclerosis. A paramyxovirus-induced inflammatory reaction].

The results indicate that otosclerosis is an inflammatory reaction of the otic capsule initiated or caused by paramyxovirus and/or rubella virus.

Otosclerosis—an inflammatory disease of the otic capsule of viral aetiology?

A viral aetiology of otosclerosis as an inflammatory vasclar reaction of the otic capsule initiated or caused by the viruses of measles, rubella and mumps is favoured.

Nachweis von masern- und rötelnspezifischen Antigenen in der enchondralen Verknöcherungszone bei der Otosklerose*

There is considerable similarity of the histological features of active otosclerosis and Paget's disease and the probable presence of viral antigens in the otosclerotic footplate of the stapes of 15 patients has been investigated by means of immunohistochemical methods.

[Immunohistochemical findings in otosclerotic lesions].

It is found that a large fraction of the lymphoid cells are antigen-primed T-cells expressing an alpha/beta T-cell receptor in association with CD3 molecules on their surfaces, which is crucial for the initiation of a local immune response.

Morphologic and immunohistochemical observation of otosclerotic stapes: a preliminary study.

Evidence of measles virus RNA in otosclerotic tissue.

By use of the very sensitive polymerase chain reaction technique, evidence is given that otosclerosis is a measles-virus-associated disease of the otic capsule and it is hypothesized that the viral infection acts as at least one pathogenetic factor during the development of this obscure, locally restricted inflammatory bone disease.

Immunohistochemistry of otosclerosis.

The application of antibodies against paramyxovirus and rubella virus antigens reproducibly determined the expression of these antigen at different sites in the otosclerotic stapes, but also in the epithelial cells of the overlying middle ear mucosa.

Experimental cytomegalovirus infection: viremic spread to the inner ear.

Qualitativer Nachweis von Immunglobulinen im menschlichen Saccus endolymphaticus

The presence of free and local bound immunoglobulins exclusively in the region of the endolymphatic sac postulates and immunologic defense mechanism of this organ for the inner ear is studied.

The epithelium of the human endolymphatic sac: immunohistochemical characterization.

The demonstration of neurosecretory antigen and neuron-specific enolase in some cells indicate that the ES epithelium may also have paracrine functions, and support the assumption that it is metabolically active and capable of secretion and resorption.