New mechanisms by which statins lower plasma cholesterol1

@article{Brunengraber2016NewMB,
  title={New mechanisms by which statins lower plasma cholesterol1},
  author={Henri Brunengraber},
  journal={Journal of Lipid Research},
  year={2016},
  volume={57},
  pages={1325 - 1326},
  url={https://api.semanticscholar.org/CorpusID:36935161}
}
A comprehensive study of the influence of three different statins on a number of parameters that regulate cholesterol metabolism in normal mice, finding that chronic treatment of mice with statins markedly stimulates cholesterol synthesis but to a different degree for each compound.
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Cholesterol synthesis is paradoxically increased upon statin treatment in mice, however, statins potently stimulate the excretion of cholesterol from the body, which sheds new light on possible mechanisms underlying the cholesterol-lowering effects of statins.

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