• Corpus ID: 20629435

Interactions of HepG2 Cells on Biomaterials with Various Surface Properties

@article{Lu2006InteractionsOH,
  title={Interactions of HepG2 Cells on Biomaterials with Various Surface Properties},
  author={Jui-Nan Lu and Tai-Horng Young},
  journal={2006 International Conference on Biomedical and Pharmaceutical Engineering},
  year={2006},
  pages={285-289},
  url={https://api.semanticscholar.org/CorpusID:20629435}
}
Results indicated that HepG2 on hydrophilic surface, such as PVA would tend to aggregate and form non-attached multicellular clump, and on the other hand, cells adhere and spread well on the hydrophobic surface,Such as EVAL and TCPS, which is a good culturing system to protect cell from external force.
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12 References

Membranes for biohybrid liver support systems--investigations on hepatocyte attachment, morphology and growth.

Fibronectin matrix formation by human fibroblasts on surfaces varying in wettability.

It is demonstrated that the decreasing wettability of the materials significantly reduced endogenous fibronectin deposition on the substratum, and an ELISA method has been implemented to quantify fibronECTin matrix formation as a possible measure of the biocompatibility of materials.

A scanning electron microscope study of cell adhesion and spreading in vitro.

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Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

Membranes for dialysis.

In the submitted review the authors give an account of contemporary problems of membranes for dialysis available at present and outline demands on the development of modern membranes and their problems in future.