In vivo studies on halogen compound interactions. I. Effects of carbon tetrachloride plus 1,2-dibromoethane on liver necrosis.
@article{Danni1988InVS,
title={In vivo studies on halogen compound interactions. I. Effects of carbon tetrachloride plus 1,2-dibromoethane on liver necrosis.},
author={Oliviero Danni and Manuela Aragno and Giancarlo Ugazio},
journal={Research communications in chemical pathology and pharmacology},
year={1988},
volume={61 3},
pages={
377-90
},
url={https://api.semanticscholar.org/CorpusID:19430758}
}Investigation of the hepatotoxicity of a mixture of two halogen compounds--carbon tetrachloride (CT) and 1,2-dibromoethane (DBE) used in association--is reported, finding the importance of lipid peroxidation in the pathogenesis of this potentiation is confirmed.
6 Citations
Lipid peroxidation and irreversible cell damage: synergism between carbon tetrachloride and 1,2-dibromoethane in isolated rat hepatocytes.
- 1991
Chemistry, Environmental Science
Liver AP-1 activation due to carbon tetrachloride is potentiated by 1,2-dibromoethane but is inhibited by alpha-tocopherol or gadolinium chloride.
- 1999
Chemistry, Environmental Science
Potentiating effects of chlorinated hydrocarbons on carbon tetrachloride toxicity in isolated rat hepatocytes and plasma membranes.
- 1991
Environmental Science, Chemistry
Change of liver metabolism of 1,2‐dibromoethane during simultaneous treatment with carbon tetrachloride
- 1993
Chemistry, Environmental Science
The combination of carbon tetrachloride and 1,2‐dibromoethane in isolated rat hepatocytes led to a significant potentiation of both lipid peroxidation and of plasma membrane damage observed after a single treatment with CCl4, and the amount of DBE reactive metabolities covalently bound to hepatocyte protein was significantly enhanced in the presence of CCl 4.