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Erenumab Decreases Headache-Related Sick Leave Days and Health Care Visits: A Retrospective Real-World Study in Working Patients with Migraine

It is suggested that in addition to the effect on the monthly number of migraine days documented in clinical trials, erenumab can significantly reduce the number of headache-related sick leave days and health care visits in employed patients with migraine managed in routine clinical practice.
Springer Nature (opens in a new tab)

Recurrent hospitalizations are associated with increased mortality across the ejection fraction range in heart failure

A large cohort with 12 years' follow-up time was analysed to better define the characteristics of HF phenotypes in Finland and found that patients with preserved left ventricular ejection fraction are more likely to have HF.
Wiley (opens in a new tab)

DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

There were only minimal associations of DNA methylation with childhood and adolescent BMI, compatible with the hypothesis thatDNA methylation differences are mostly a consequence rather than a cause of obesity.
Springer Nature (opens in a new tab)

My Migraine Voice survey: disease impact on healthcare resource utilization, personal and working life in Finland

The emotional and functional burden was high, and the societal burden increased by frequency and severity of migraine, as shown by higher HCRU and reduced work productivity.
Springer Nature (opens in a new tab)

Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis

Evidence is found that DNA methylation at birth is associated with ADHD, and future studies are needed to confirm the utility of methylation variation as biomarker and its involvement in causal pathways.
Springer Nature (opens in a new tab)

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

A meta-analysis of genome-wide association studies of alcohol consumption from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia identifies 46 new common loci associated with alcohol consumption and suggests genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.
Springer Nature (opens in a new tab)

Retrospective, Registry-based, Cohort Investigation of Clinical Outcomes in Patients with Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma in Finland

It is suggested that identifying patient and tumour factors associated with poor disease outcome could be important when determining appropriate treatment and follow-up; however, further studies are necessary.
PDF (opens in a new tab)

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

A meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood found no consistent evidence for any robust associations between mother-child anxiety and DNAm in cord blood.
Springer Nature (opens in a new tab)

Real-world data on diffuse large B-cell lymphoma in 2010-2019: usability of large data sets of Finnish hospital data lakes.

Finnish data lakes represent an efficient way to analyze large DLBCL data sets and provide a tool for developing recording practices in routine care, according to real-world data on diffuse large B-cell lymphoma.
PubMed (opens in a new tab)

Pediatric Short Bowel Syndrome: Real-World Evidence on Incidence and Hospital Resource Use From a Finnish Data Lake

SBS-IF is a rare disease with a relatively low number of patients treated at each hospital district, but the burden on the hospital system, as well as the patient’s family, is especially high at the onset as the newborns with SBS-if spend a significant part of their first year of life in the hospital.
Wolters Kluwer (opens in a new tab)
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