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Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension.

The clinical implications of vascular remodeling, the differences between vascular smooth muscle cell remodeling in conductive and resistance arteries, the genetic factors associated with vascular smooth Muscle cell function in hypertensive patients are discussed, and a prospective assessment of current and future research and pharmacological targets for the treatment of hypertension are provided.
Wolters Kluwer (opens in a new tab)

ATF3 Coordinates Antitumor Synergy between Epigenetic Drugs and Protein Disulfide Isomerase Inhibitors

A new class of protein disulfide isomerase (PDI) inhibitors that significantly and synergistically enhance the antitumor activity of HDACi in glioblastoma and pancreatic cancer preclinical models is described.
AACR (opens in a new tab)

Histone modifiers at the crossroads of oncolytic and oncogenic viruses.

The current knowledge about the impact of using epigenetic drugs in tumors positive for oncogenic viruses or as therapeutic combinations with oncolytic viruses is reviewed.
PubMed (opens in a new tab)

NOTCH induced MDSC recruitment after oHSV virotherapy in CNS cancer models modulates anti-tumor immunotherapy.

Findings support the use of NOTCH inhibition in conjunction with oHSV therapy and show that NOTCH signaling significantly correlated with a higher myeloid cell infiltration and activated a CD8 dependent anti-tumor memory response, resulting in a therapeutic benefit.
PubMed (opens in a new tab)

Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure

Translocalization of Panx1 to Cav1-enriched caveolae in VSMCs augments the release of purinergic stimuli necessary for proper adrenergic-mediated vasoconstriction and blood pressure homeostasis.
Wolters Kluwer (opens in a new tab)

Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction

Supplemental Digital Content is available in the text. Rationale: Increasing prevalence of obesity and its associated risk with cardiovascular diseases demands a better understanding of the…
Wolters Kluwer (opens in a new tab)

TAMI-11. IMPACT OF oHSV ACTIVATED NOTCH SIGNALING IN TUMOR MICROENVIRONMENT, AND ITS IMPACT ON ANTI-TUMOR IMMUNITY

Overall these studies have uncovered a significant impact of oHSV therapy on GBM tumor microenvironment and presents opportunities for combination therapies that can help improve therapeutic benefit and anti-tumor immunity.
Publisher (opens in a new tab)

Reductions in VLDL and remnant cholesterol through inhibition of ANGPTL3 protein synthesis: An analysis from TRANSLATE-TIMI 70

Publisher (opens in a new tab)

Replacement Therapies in Metabolic Disease.

With the next generation of treatments approaching, this review examines the recent decades of replacement therapy innovation in metabolic disease and discusses the challenges and opportunities for the nextgeneration of treatments.
PubMed (opens in a new tab)

Endothelial Hba1 Regulates Exercise Fitness in Mice

It is concluded that endothelial Hba1 plays an important role in vascular function and exercise performance and a treadmill running test as a measure of acute endurance capacity was used to examine the role of endothelium Hbα in exercise hyperemia.
Wiley (opens in a new tab)
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