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Maternal Hypertensive Pregnancy Disorders and Mental Disorders in Children

Maternal hypertensive pregnancy disorders carry adverse consequences for offspring mental health, and preterm and small-for-gestational-age births and neonatal intensive care unit admission partially mediated the effects of any and severe preeclampsia on offspring mental disorders.
Wolters Kluwer (opens in a new tab)

Maternal Licorice Consumption During Pregnancy and Pubertal, Cognitive, and Psychiatric Outcomes in Children

Girls and boys exposed to high maternal glycyrrhizin consumption scored 7 (95% CI: 3.1, 11.2) points lower on tests of intelligence quotient, had poorer memory, and had 3.3-fold higher odds of attention deficit/hyperactivity disorder problems compared with children whose mothers consumed little to no glycyRrhiz in.
Wolters Kluwer (opens in a new tab)

Infant growth after preterm birth and neurocognitive abilities in young adulthood.

Within a VLBW group with high variability in early growth, faster growth from birth to term is associated with better neurocognitive abilities in young adulthood, and these outcomes were predicted, in particular, by early postnatal head growth.
PubMed (opens in a new tab)

Common mental disorders in young adults born late-preterm

Using a cohort born during the advanced neonatal and early childhood care, it is found that not all individuals born preterm are at risk for common mental disorders in young adulthood – those born late-preterm are not, while those born early-pre term are at a higher risk.
Cambridge Press (opens in a new tab)

Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

Children whose mothers reported higher levels of cumulative maternal stressful life events during pregnancy exhibited differential methylation of cg26579032 in ALKBH3, and differences in DNA methylation at these loci may provide novel insights into potential mechanisms of neurodevelopment in offspring.
Springer Nature (opens in a new tab)

Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression.

This work shows that glucocorticoids increase a specific type of basal progenitors that has been shown to contribute to cortical expansion in gyrified species and provides a cellular and molecular pathway for the effects of glucocorticoids on human neurogenesis that relates to lasting postnatal phenotypes.
PubMed (opens in a new tab)

Maternal early‐pregnancy ferritin and offspring neurodevelopment: A prospective cohort study from gestation to school age

High maternal ferritin during pregnancy was associated with poorer child cognitive abilities and smaller brain volume, and Maternal iron status during pregnancy may be associated with offspring neurodevelopment.
PubMed (opens in a new tab)

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

A meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood found no consistent evidence for any robust associations between mother-child anxiety and DNAm in cord blood.
Springer Nature (opens in a new tab)

Neurocognitive outcome in young adults born late‐preterm

This study examined whether late‐preterm birth was associated with neurocognitive deficit in young adulthood, and whether small for gestational age (SGA) birth amplified any adversity.
Wolters Kluwer (opens in a new tab)

Very Low Birth Weight, Infant Growth, and Autism-Spectrum Traits in Adulthood

Among those born preterm at VLBW, the risk for higher levels of autism-spectrum traits, particularly related to social interaction, may persist into adulthood, suggesting that targeted interventions could aid long-term neurodevelopment.
AAP (opens in a new tab)
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