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Lifestyle interventions to reduce endocrine-disrupting phthalate and phenol exposures among reproductive age men and women: A review and future steps

There is a paucity of interventions to prevent phthalate and phenol exposures during the reproductive years, especially among men, and it is recommended that additional, larger clinical and community-based intervention studies to reduce EDC exposure are recommended.
PubMed (opens in a new tab)

Can increasing years of schooling reduce type 2 diabetes (T2D)?: Evidence from a Mendelian randomization of T2D and 10 of its risk factors

A protective effect of more schooling years against type 2 diabetes and 10 of its attendant risk factors is revealed, implying that strategies to retain adults in higher education may help reduce the risk of metabolic morbidity and mortality.
Springer Nature (opens in a new tab)

Investigating the effects of lycopene and green tea on the metabolome of men at risk of prostate cancer: The ProDiet randomised controlled trial

An intervention to increase lycopene intake altered the serum metabolome of men at risk of prostate cancer and Lycopene lowered levels of pyruvate, which the Mendelian randomisation analysis suggests may be causally related to reduced prostate cancer risk.
Wiley (opens in a new tab)

Using multiple Mendelian randomization approaches and genetic correlations to understand obesity, urate, and gout

A multivariable MR of obesity, HDL, and triglycerides on urate showed obesity influenced urate when accounting for HDL and triglyceride and all the effect of obesity on gout occurred through urate.
Springer Nature (opens in a new tab)

A Mendelian randomization study of telomere length and blood-cell traits

Two-sample Mendelian randomization is performed to test whether longer telomeres cause changes to hematological traits, and data provide evidence that genetically influenced common variation in telomere length impacts hematologic traits in the population.
Springer Nature (opens in a new tab)

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study

The largest study of metabolites and prostate cancer and found no evidence of causality for a subset of the prostate cancer–metabolite associations using two-sample Mendelian randomization (MR), suggesting the 14 MR-tested metabolites are unlikely to be mechanistically important in prostate cancer risk.
AACR (opens in a new tab)

Circulating Glutamine and Alzheimer’s Disease: A Mendelian Randomization Study

Findings lend credence to the emerging story supporting the modifiability of glutamine/glutamate metabolism for the prevention of cognitive decline and may be worth exploring in future efforts to prevent and/or treat Alzheimer’s disease.
PubMed (opens in a new tab)

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

A meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood found no consistent evidence for any robust associations between mother-child anxiety and DNAm in cord blood.
Springer Nature (opens in a new tab)

Otologic manifestations of Fanconi anemia and other inherited bone marrow failure syndromes

The objective was to characterize these in patients with Fanconi anemia, dyskeratosis congenita, Diamond–Blackfan anemia (DBA), and Shwachman–Diamond syndrome, and to determine the association between physical findings and hearing loss.
Wiley (opens in a new tab)

A multivariable Mendelian randomization to appraise the pleiotropy between intelligence, education, and bipolar disorder in relation to schizophrenia

A multivariable Mendelian randomization of schooling years and bipolar disorder reveals that the increased risk of schizophrenia conferred by more schooling years is an artefact of bipolar disorder – not education.
Springer Nature (opens in a new tab)
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