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Fed‐batch and perfusion culture processes: Economic, environmental, and operational feasibility under uncertainty

The deterministic analysis indicated that the ATF perfusion strategy has the potential to offer cost of goods savings of 20% when compared to conventional fed‐batch manufacturing processes when a fivefold increase in maximum viable cell densities was assumed.
Wiley (opens in a new tab)

Optimising the design and operation of semi-continuous affinity chromatography for clinical and commercial manufacture.

An integrated experimental and modelling approach to evaluate the potential of semi-continuous chromatography for the capture of monoclonal antibodies (mAb) in clinical and commercial manufacture found that PCC capture chromatography would offer more significant savings in direct costs for early-stage clinical manufacture (proof-of-concept) than for late-stageclinical or commercial manufacture.
PubMed (opens in a new tab)

Integrated continuous bioprocessing: Economic, operational, and environmental feasibility for clinical and commercial antibody manufacture

This paper presents a systems approach to evaluating the potential of integrated continuous bioprocessing for monoclonal antibody (mAb) manufacture across a product's lifecycle from preclinical to…
Wiley (opens in a new tab)

Toward Greener Therapeutic Proteins

Publisher (opens in a new tab)

Modelling and Control of Sustained Oscillations in the Continuous Emulsion Polymerization of Vinyl Acetate

Improving Agricultural Practices Through Water-flow Modeling and Visualization

Computer-Aided Design and Evaluation of Batch and Continuous Multi-Mode Biopharmaceutical Manufacturing Processes

A dynamic decision-support tool that can design and analyse multimode biopharmaceutical manufacturing processes by performing deterministic and stochastic analysis using Monte Carlo simulation data generated by a discrete-event simulation tool is described.
Publisher (opens in a new tab)

Variable coefficient control of a wave-energy device

Improve Agricultural Practices through Waterflow Modeling & Visualization

Evaluating the economic and operational feasibility of continuous processes for monoclonal antibodies

This presentation will evaluate the potential of integrated batch and continuous processes via a series of case studies based on the commercial manufacture of monoclonal antibodies via a prototype dynamic decision-support tool built at University College London encompassing process economics, discrete-event simulation, and uncertainty analysis so as to enable a holistic assessment.
Publisher (opens in a new tab)
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