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Alzheimer disease brain atrophy subtypes are associated with cognition and rate of decline

An increased HV:CTV ratio was predictive of faster clinical decline in participants with AD who were clinically indistinguishable at baseline except for a greater dysexecutive presentation, driven mostly by the amount of cortical rather than hippocampal atrophy.
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Topographic staging of tau positron emission tomography images

It has been proposed that the signal distribution on tau positron emission tomography (PET) images could be used to define pathologic stages similar to those seen in neuropathology.
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Tau Subtypes of Alzheimer’s Disease Determined in vivo Using Flortaucipir PET Imaging

At autopsy, individuals with Alzheimer’s disease (AD) exhibit heterogeneity in the distribution of neurofibrillary tangles in neocortical and hippocampal regions. Subtypes of AD, defined using an…
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Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition

Relationship between self– and informant memory concerns and tau aggregation was assessed in adults at risk for Alzheimer's disease (AD).
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IC‐P‐086: COMPARISON BETWEEN THREE VOLUMETRIC MRI Z‐SCORE NORMING METHODS ACROSS THE ALZHEIMER DISEASE SPECTRUM

This simple method recapitulates features reported using more complex subtyping algorithms, including more impaired executive function in the Cortical subtype, which is easily implementable, enables vMRI-based stratification in AD trials, and may help as a covariate in models explaining different cognitive presentations.
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Predicting short-term conversion from CIS to MS

Clinically isolated syndrome (CIS) describes a first symptomatic neurologic episode that is consistent with multiple sclerosis (MS), lasts at least 24 hours, occurs in the absence of fever or…
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P1‐485: COMPARISON BETWEEN THREE VOLUMETRIC MRI Z‐SCORE NORMING METHODS ACROSS THE ALZHEIMER DISEASE SPECTRUM

Higher levels of CCK predicted better cognitive outcomes and more gray matter in memory-specific regions, yet were also related to more tau species deposition, suggesting that as the disease is progressing, CCK levels increase in efforts to protect against further damage.
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P1‐372: SUBTYPES OF NEURODEGENERATION IN ALZHEIMER DISEASE: A HEAD‐TO‐HEAD COMPARISON OF FOUR BRAIN ATROPHY SUBTYPE ALGORITHMS IN ADNI

This study demonstrates the potential utility of structural connectivity as features to classify the individuals with high risk for developing AD and suggested potential connectome-based biomarkers for discriminating risk populations of AD from healthy elderly.
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IC‐P‐162: RELATIONSHIPS BETWEEN FLORTAUCIPIR TAU BINDING AND REGIONAL BRAIN ATROPHY IN AMYLOID POSITIVE SUBJECTS ACROSS THE ALZHEIMER'S DISEASE SPECTRUM

The author’s research interests include cognitive neuroscience, neuroimaging, and neurosurgery, as well as basic and applied neuroscience.
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P4‐105: A SIMPLE METHOD FOR DEFINING ATROPHY SUBTYPES IN INDIVIDUAL SUBJECTS ACROSS THE ALZHEIMER'S DISEASE SPECTRUM

Positive correlation between FDG uptake and sensorimotor SBR (corrected for cognitive SBR) was observed in bilateral visual association Cortex, confirming that altered cerebral glucose metabolism is associated with nigrostriatal degeneration in PD.
Wiley (opens in a new tab)
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