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Marginal Structural Models to Assess Delays in Second-Line HIV Treatment Initiation in South Africa

Even small delays in switch to second-line ART were associated with increased death andSecond-line failure among patients with low CD4 counts on first-line treatment, and there is opportunity for healthcare providers to switch patients tosecond-line more quickly.
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Cost-Effectiveness of Alternative Strategies for Initiating and Monitoring Highly Active Antiretroviral Therapy in the Developing World

Treating patients with HIV according to developed versus developing world guidelines is highly cost-effective and may result in substantial long-term savings.
Wolters Kluwer (opens in a new tab)

Developing a predictive risk model for first-line antiretroviral therapy failure in South Africa

A predictive model is developed to identify patients at the greatest risk of virologic failure on first‐line antiretroviral therapy, and to estimate the proportion of patients needing second‐line ART over five years on treatment.
Wiley (opens in a new tab)

Recent Developments in Hiv Treatment and Their Dissemination in Poor Countries

The priority of developing countries remains increased scale up of ART, but there is also a need to acquire new drugs in order to tackle toxicity and drug-resistance, both of which threaten the sustainability of such programmes.
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Carbamazepine and Its Metabolites in Epileptic Patients

The results showed an association of high levels of metabolites with poor response to carbamazepine therapy, which may be due to competition by inactive dihydroxy metabolite to the site(s) action of the parent drug in the brain.

The impact of bone marrow stromal antigen-2 (BST2) gene variants on HIV-1 control in black South African individuals.

The data suggest that the possession of select BST2 genotype combinations may be implicated in HIV-1 disease progression and natural spontaneous control, a finding predominantly driven by the _GG_AG combination.
PubMed (opens in a new tab)

Cohort profile: the Right to Care Clinical HIV Cohort, South Africa

The data have been used to identify rates and predictor of first-line failure, to identify predictors of mortality for patients on second-line HIV treatment, and to show that adolescents and young adults are at increased risk of unsuppressed viral loads compared with adults.
BMJ (opens in a new tab)

Effects of Large Doses of Vitamin-A On Brain Acetylcholinesterase in the Experimental Mouse

Treatment outcomes of HIV-positive patients on first-line antiretroviral therapy in private versus public HIV clinics in Johannesburg, South Africa

It is suggested that the type of clinic at which ART patients initiate and receive treatment can have an impact on treatment outcomes, and differences in treatment outcomes between the two HIV clinics.
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Analysis of Cis‐acting Sequences Required for Operation of the Erythropoietin 3’Enhancer in Different Cell Lines a

Analysis of a regulatory cis-acting sequence lying 3' to the EPO gene is described and evidence of a widespread oxygen-sensing system that interacts with specific sites within this sequence is provided, suggesting that such a system might be regulating the expression of other genes in cells not specialized for the production of erythropoietin.
Wiley (opens in a new tab)
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