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Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy

This study delivers a strong antitumour strategy by targeting lysosome to induce divergent metabolic programs in macrophages and tumours for cancer immunotherapy and reveals the crucial strategies of macrophage-based metallodrugs discovery that are able to treat both immunologically “hot” and “cold” cancers.
Springer Nature (opens in a new tab)

Enhancing Hybrid Upconversion Nanosystems via Synergistic Effects of Moiety Engineered NIR Dyes.

The design of the NIR dyes suggests a new scope to search for more efficient upconversion nanohybrids and introduces a bulky moiety, 4-(1,2,2-triphenylvinyl)-1,1'-biphenyl (TPEO), to enhance its quantum yield by suppressing the bond rotation and improve the stability by deactivating the photoinduced oxidation.
PubMed (opens in a new tab)

A hybrid strategy to enhance small-sized upconversion nanocrystals.

Upconversion nanoparticles (UCNPs) are characterized by high photostability, narrow spectral bands, excellent tuneability, and low biotoxicity, facilitating a broad range of biomedical applications.…
PubMed (opens in a new tab)

Nanoparticles give mice infrared vision

The injection of rare-earth-doped upconversion nanoparticles into the eyes of mice allows them to visualize near-infrared light with a wavelength of ~1 μm.
Springer Nature (opens in a new tab)

Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors

Findings indicated that compound 9u was potential for developing as antitumor reagent, which could induce early apoptosis of A549 cells and arrest the cells in G2/M phase.
Taylor & Francis (opens in a new tab)

Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells

Compound 4d is potential to develop as novel anti-cancer drug because molecular docking and ADMET studies showed that compound 4d could closely form many hydrogen bonds with EGFRwt-TK.
Taylor & Francis (opens in a new tab)

A stoichiometric terbium-europium dyad molecular thermometer: energy transfer properties

As the first molecular-based thermometer with clear validation of the metal ratio and a fixed distance between the metal pairs, these dinuclear complexes can be used as new materials for temperature sensing and can provide a new platform for understanding the energy transfer between lanthanide ions.
Springer Nature (opens in a new tab)

Effects of europium spectral probe interchange in Ln-dyads with cyclen and phen moieties.

The results support the concept that the lowest excited states of the complexes are localized on individual ligands, in the present case phen, rather than delocalized over the entire molecule.
PubMed (opens in a new tab)

1,3-Diaminopropane Bisborane as a Hydrogen Storage Media

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Thermo-mechanical stress modeling and experimental investigation on micro-cracks in tilling ribbon photovoltaic modules during lamination and mechanical load test

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