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A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis

Findings reveal how microglia can directly alter the molecular landscape of AD, and suggest critical roles for microglia in regulating APOE in the AD brain.
Springer Nature (opens in a new tab)

Basic Science and Pathogenesis.

A human 3D cell culture model allowing the formation of neurospheres and a chronic Aß stimulation protocol to mimic amyloidosis as a novel human AD in vitro model is presented to reveal new potential therapeutic pathways.
PubMed (opens in a new tab)

A human iPSC‐derived neurosphere model to study functional and transcriptomic properties of microglial neuroprotection in AD

A 3D human iPSC‐derived neurosphere model is developed to better characterize how microglia respond to Aβ pathology in Alzheimer's disease.
Wiley (opens in a new tab)

Single-Cell Approaches Define the Murine Leptomeninges: Cortical Brain Interface as a Distinct Cellular Neighborhood Composed of Neural and Non-neural Cell Types

The data provide a molecular/cellular resource describing the brain interface cell types and their interactions, thereby enabling future studies investigating how this distinct cellular compartment regulates CNS:periphery interactions.
SFN (opens in a new tab)

Single cell approaches define the murine leptomeninges:cortical brain interface as a distinct cellular neighborhood comprised of neural and nonneural cell types

Single cell RNA-sequencing and single cell spatial transcriptomics are used together with morphological lineage tracing and immunostaining to analyze the adult murine cortex to provide a molecular/cellular resource describing the brain interface cell types and their interactions, thereby enabling future studies asking how this distinct cellular compartment regulates CNS:periphery interactions.
Publisher (opens in a new tab)
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