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A Plasmodium-derived nanoparticle vaccine elicits sterile protection against malaria in mice

A potent multivalent malaria vaccine is developed using an engineered Plasmodium falciparum pyridoxal 5′-phosphate (PLP) synthase as a nanoparticle that presents a designed P. falciparum circumsporozoite protein immunogen and achieves full sterile protection in mice.
Springer Nature (opens in a new tab)

A combined designed CSP and Pfs48/45 infection and transmission blocking vaccine for malaria

A self-assembled ferritin nanoparticle vaccine that simultaneously presents designed immunogens CSPj5c and 17-4 from the infection-blocking circumsporozoite and the transmission-blocking Pfs48/45 antigens is generated and is therefore a promising multistage malaria vaccine with a potential role in malaria control.
Springer Nature (opens in a new tab)

RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination.

This work introduces those enhancing amino acid changes into a full-length spike (FL-S-2P) ectodomain representative of most approved vaccine antigens that can be incorporated into the FL-S-2P protein without negatively effecting expression or stability.
PubMed (opens in a new tab)
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