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Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies

This work systematically integrated large-scale multimodal neuroimaging data from functional magnetic resonance imaging, diffusion tractography, cortical morphometry and positron emission tomography to simulate how anatomically guided transitions between cognitive states can be reshaped by neurotransmitter engagement or by changes in cortical thickness.
Springer Nature (opens in a new tab)

Longitudinal multimodal neuroimaging after traumatic brain injury

It is found that flumazenil-PET binding potential was significantly reduced in frontal and thalamic regions in brain injured subjects, consistent with neuronal loss, with partial recovery over time, and this pattern suggests that heightened intrinsic regional activity may serve as a compensatory mechanism in regions increasingly disconnected due to progressive axonal degradation.
PubMed (opens in a new tab)

Krakencoder: a unified brain connectome translation and fusion tool

The Krakencoder is a joint connectome mapping tool that simultaneously bidirectionally translates between structural and functional connectivity, and between different atlases and processing choices via a common latent representation, demonstrating exceptional accuracy and individual-level identifiability.
Springer Nature (opens in a new tab)

Brain activity dynamics after traumatic brain injury indicate increased state transition energy and preference of lower order states

Mild TBI causes a delayed shift toward lower-order brain states and energetic changes reflect increased top-down vs. bottom-up processing demands, which are linked to changes in cognitive performance post-TBI.
PubMed (opens in a new tab)

Evaluating structural connectivity disruption after stroke: individual tractography or the use of a model-based approach?

The model-based framework is efficient for large-scale studies, while individual tractography may better capture patient- and age-specific SCD patterns, with larger differences in older adults.
PubMed (opens in a new tab)

Altered structural connectivity and functional brain dynamics in individuals with heavy alcohol use elucidated via network control theory.

This work demonstrates that whole-brain, multimodal imaging information can be combined under a network control framework to identify and evaluate neurobiological correlates and mechanisms of heavy alcohol use.
PubMed (opens in a new tab)

TSPO-PET reveals higher inflammation in white matter disrupted by paramagnetic rim lesions in multiple sclerosis

It is suggested that patients with PRLs may exhibit more diffuse WM inflammation in addition to higher inflammation along WM tracts disrupted by PRLs compared to non-PRLs, which could contribute to larger lesion volumes and faster disability progression.
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Predicting Language Function Post-Stroke: A Model-Based Structural Connectivity Approach

Connectivity disruption of the language network adds predictive value beyond lesion volume, initial language function, and non-verbal cognitive ability and constitutes a significant advancement toward practical clinical application.
SAGE (opens in a new tab)

TSPO-PET Reveals Higher Inflammation in White Matter Disrupted by Paramagnetic Rim Lesions in Multiple Sclerosis

This study suggests that patients with PRLs may exhibit more diffuse WM inflammation in addition to higher inflammation along WM tracts disrupted by PRLs compared to non-PRLs, which could contribute to larger lesion volumes and faster disability progression.
PubMed (opens in a new tab)

610. Family History of Substance Use Disorder Alters Brain Dynamics in a Sex-Dependent Manner in Substance-Naïve Youth: Findings From the ABCD Study

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