Neutrophils: Novel Contributors to Estrogen-Dependent Intracranial Aneurysm Rupture Via Neutrophil Extracellular Trap Formation
- D. PatelWilliam S. Dodd B. Pollock
- 2023
Medicine
Targeting NETosis may lead to the development of novel therapeutics to protect against IA progression, particularly IA rupture in post-menopausal women.
CXCL1: a novel therapeutic target to increase aneurysm healing after coil embolization.
- D. PatelMelanie E. Martinez B. Hoh
- 10 February 2026
Medicine
Frontiers in stroke
Systemic CXCL1 neutralization is a promising potential therapy to improve aneurysm healing by modulating the inflammatory response after coiling by improving aneurysm healing in female and male mice.
PREDICTORS OF ANEURYSM RECURRENCE AFTER ENDOVASCULAR EMBOLIZATION WITH THE SMART COIL SYSTEM
- M. AnadaniM. Sattur K. Hosaka
Medicine, Engineering
A 69-year-old female patient presented with a ruptured small basilar apex aneurysm, and the patient remained stable post-operatively with Balloon-assisted coil embolization, and was discharged home on dual antiplatelet therapy.
Neutrophils: Novel Contributors to Estrogen‐Dependent Intracranial Aneurysm Rupture Via Neutrophil Extracellular Traps
- D. PatelW. DoddBrandon Lucke‐WoldMuhammad Abdul Baker ChowdhuryK. HosakaB. Hoh
- 27 October 2023
Medicine, Biology
Targeting NETosis appears to be an underlying mechanism for neutrophil‐mediated IA rupture in estrogen deficiency, which may lead to the development of novel therapeutics to protect against IA rupture in the setting of estrogen deficiency.
Subarachnoid hemorrhage-associated brain injury and neurobehavioral deficits are reversed with synthetic adropin treatment through sustained Ser1179 phosphorylation of endothelial nitric oxide…
An endothelial nitric oxide synthase (eNOS)-dependent effect of synthetic adropin treatment that reverses the deleterious effects of SAH is reported, establishing the potential of adropin or adropin mimetics to improve outcomes following subarachnoid hemorrhage.