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Mexican Biobank advances population and medical genomics of diverse ancestries

Insight into the genetic histories of individuals in Mexico is provided and their complex trait architectures are dissected, both crucial for making precision and preventive medicine initiatives accessible worldwide.
Springer Nature (opens in a new tab)

Whole-genome sequencing of 490,640 UK Biobank participants

    Keren Bjarni V. Liping Jimmy Eleanor Yancy Kousik Zhuoyi Carss Halldorsson Hou Liu Wheeler Lo Kundu Huang LKeren Bjarni V. Liping Jimmy Eleanor Yancy Kousik Zhuoyi Carss Halldorsson Hou Liu Wheeler Lo Kundu Huang L Ole Schulz-Trieglaff
    Biology, Medicine
    Nature
  • 6 August 2025
This dataset, representing a large collection of whole-genome sequencing data that is available to the UK Biobank research community, will enable advances of the understanding of the human genome, facilitate the discovery of diagnostics and therapeutics with higher efficacy and improved safety profile, and enable precision medicine strategies with the potential to improve global health.
Springer Nature (opens in a new tab)

Whole-genome sequencing of half-a-million UK Biobank participants

This landmark dataset, representing the largest collection of WGS and available to the UK Biobank research community, will enable advances into the understanding of the human genome, and facilitate the discovery of new diagnostics, therapeutics with higher efficacy and improved safety profile, and enable precision medicine strategies with the potential to improve global health.
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The genetic architecture of gene expression in individuals of African and European ancestry

It is shown that comparisons of heritability of gene expression could be confounded by population substructure, but that variation in local genetic ancestry did not majorly impact eQTL discovery.
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Population scale whole genome sequencing provides novel insights into cardiometabolic health

This study demonstrates that large-scale WGS provides novel mechanistic insights into human metabolic phenotypes through improved capture of coding sequences through improved capture of coding sequences.
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Abstract B014: Early-onset breast cancer and reproductive timing: results from the Mexican Teachers’ Cohort

There is limited evidence supporting the protective role of breastfeeding and only modest positive associations identified with certain patterns of hormonal contraceptive use, which underscore the importance of incorporating reproductive timing into risk stratification and prevention strategies in Mexico and throughout Latin America.
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A computational framework for defining and validating reproducible phenotyping algorithms of 313 diseases in the UK Biobank

This work developed a computational framework to harmonize EHR data, participant questionnaires, and clinical registry information, defining 313 disease phenotypes among 502,356 UK Biobank participants, establishing comprehensive disease validation profiles, improving phenotype generalizability despite inherent UKB demographic biases.
Springer Nature (opens in a new tab)
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