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Global phosphoproteomic profiling of skeletal muscle in ovarian-hormone deficient mice.

This work provides the first global phosphoproteomic analysis in females and how estrogen deficiency impacts the skeletal muscle phosphoproteinome and how the decline of estrogen in females that occurs with aging might alter the skeletal Muscle phosphorylation.
PubMed (opens in a new tab)

In vivo potentiation of post-tetanic twitch across age and sex.

Enhanced generation of twitch force of skeletal muscle using a post-tetanic potentiation method does occur in vivo and is affected by age but not sex, as there is greater twitch torque potentiation in young than old mice.
PubMed (opens in a new tab)

Global phosphoproteomic profiling of skeletal muscle in ovarian hormone-deficient female mice

It is suggested that estrogen deficiency remodels the skeletal muscle phosphoproteome which may alter phosphorylation signaling that might contribute to the loss of strength in females.
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Phosphoproteomic profiling of skeletal muscle twitch torque potentiation in ovarian hormone deficient female mice

Two label‐free quantification phosphoproteomic analyses of the tibialis anterior muscle in ovariectomized and ovarian senescent female mice after in vivo post‐tetanic potentiation protocol suggest that the similarities identified in both datasets could elucidate the molecular characteristics of muscle proteins that might contribute to decrements in muscle function observed in Ovx and Old females.
Wiley (opens in a new tab)

Natural aging and ovariectomy induces parallel phosphoproteomic alterations in skeletal muscle of female mice

Comparative analyses between Ovx/Sham and OA/YA using Ingenuity Pathway Analysis found parallel patterns of inhibition and activation across IPA-defined canonical signaling pathways and physiological functional analysis, which were similarly observed in downstream GO, KEGG, and Reactome pathway overrepresentation analysis pertaining to muscle structural integrity and contraction.
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Chronic Intermittent Ethanol Exposure Alters Behavioral Flexibility in Aged Rats Compared to Adult Rats and Modifies Protein and Protein Pathways Related to Alzheimer’s Disease

Behavioral and proteomic results identified several candidate proteins and pathways potentially associated with alcohol-induced cognitive decline in aged adults.
PubMed (opens in a new tab)
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