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SNPs in Sites for DNA Methylation, Transcription Factor Binding, and miRNA Targets Leading to Allele-Specific Gene Expression and Contributing to Complex Disease Risk: A Systematic Review

The systematic review provides evidence for the interplay between genetic and epigenetic risk factors through allele-specific gene expression in various complex multifactorial diseases.
PubMed (opens in a new tab)

Pharmacogenomic considerations for repurposing of dexamethasone as a potential drug against SARS-CoV-2 infection

The reported genetic variations that impact dexamethasone response are summarized and dexamETHasone-induced changes in transcriptome and metabolome that may influence potential treatment outcome against COVID-19 are discussed.
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Acute lymphoblastic leukemia and genetic variations in BHMT gene: Case-control study and computational characterization

Evaluated the association of BHMT with acute lymphoblastic leukemia (ALL), followed by in-silico characterization of variations in BHMT gene, finding that BHMT polymorphism showed no association with ALL.
SAGE (opens in a new tab)

In silico characterization of functional single nucleotide polymorphisms of folate pathway genes

A comprehensive computational survey of single nucleotide polymorphisms of folate pathway genes to highlight functional polymorphisms in the coding region, transcription factor binding sites, and miRNAs binding sites and may provide a foundation for future targeted mechanistic, structure‐function, and genetic epidemiological studies.
Wiley (opens in a new tab)

Periodontal Disease and Its Bi-Directional Relationship with Systemic Disease: A Survey among Medical Interns and Graduates

Publisher (opens in a new tab)

Coding SNPs in hsa-miR-1343-3p and hsa-miR-6783-3p target sites of CYP2C19 modulates clopidogrel response in individuals with cardiovascular diseases.

The role of coding mirSNP (rs4244285) in the regulation of the CYP2C19 gene through miRNAs and its implications to clopidogrel drug response prediction in the Indian population are demonstrated.
PubMed (opens in a new tab)

Development of DNA markers using next-generation sequencing approach for molecular authentication of Boerhavia diffusa L. and Tinospora cordifolia (Willd.) Miers

The adulteration of plants and their materials used in herbal formulations poses a severe health concern. Hence, there is a need to establish a reliable, cost-effective, and robust molecular…
Springer Nature (opens in a new tab)

Aberrant DNA methylation and miRNAs in coronary artery diseases and stroke: a systematic review.

A comprehensive review was performed using Pubmed, Science Direct and Scopus databases to highlight the role of DNA methylation and miRNAs in CAD and stroke subjects and found mir-223 hypomethylation and altered expression were associated with cerebral infarction and stroke.
PubMed (opens in a new tab)

MirSNPs in clopidogrel metabolism genes predict cardiovascular disease risk: a case-control study and meta-analysis.

The meta-analysis showed the population-specific impact of Pon1 rs662 on South Asian and Middle East populations and the miRNA hsa-miR-224-5p showed differential expression in the PON1 rs3917577 GG genotype.
PubMed (opens in a new tab)

Authentication of Balaa in selected traditional formulations using ITS2 and matK DNA barcoding markers

Investigation on the detection of Balaa (Sida cordifolia L.) in the market formulations using Internal Transcribed Spacer 2 (ITS2) region and Maturase K (matK) barcoding markers using CTAB technique shows that for validating the presence of a particular species usage in the commercial formulation, complete gene sequencing of the claimed species/original species and accepted alternatives have to be made available for comparative studies.
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