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[Primary sclerosing cholangitis].

During treatment with UDCA stenoses of major ducts may develop and early endoscopic dilatation is highly effective and in patients with endstage disease, UDCA is not effective and liver transplantation is indicated.
PubMed (opens in a new tab)

Development of dominant bile duct stenoses in patients with primary sclerosing cholangitis treated with ursodeoxycholic acid: outcome after endoscopic treatment.

Endoscopic opening of dominant stenoses is effective and appears to be a valuable addition to the medical treatment of patients with primary sclerosing cholangitis.
PubMed (opens in a new tab)

Herpes simplex virus sepsis and acute liver failure

It is a generally accepted consensus to begin antiviral therapy pre‐emptively with acyclovir in cases of acute liver failure of unknown origin, in which high urgency (HU) liver transplantation remains the only therapeutical option.
Wiley (opens in a new tab)

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

A genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls found non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11.
Nature (opens in a new tab)

Effect of scheduled endoscopic dilatation of dominant strictures on outcome in patients with primary sclerosing cholangitis

In a large retrospective study, regular ERCP with endoscopic balloon dilatation significantly benefits patients with PSC with DS, diagnosed both at initial presentation and during surveillance, even if asymptomatic.
BMJ Publishing Group (opens in a new tab)

Bacteriobilia and fungibilia are associated with outcome in patients with endoscopic treatment of biliary complications after liver transplantation

Bacteriobilia and fungibilia can frequently be detected by routine microbiological sampling in patients after OLT and regular bile sampling is recommended since the presence of difficult-to-treat multiresistant strains is unpredictable.
Thieme (opens in a new tab)

Efficacy of ursodeoxycholic acid treatment and endoscopic dilation of major duct stenoses in primary sclerosing cholangitis. An 8-year prospective study.

The actuarial Kaplan-Meier survival probabilities without liver transplantation after treatment with ursodeoxycholic acid and dilation of major duct stenoses were significantly improved compared to the predicted survival rates with p=0.001.
PubMed (opens in a new tab)

Immunogenicity of two accelerated hepatitis B vaccination protocols in liver transplant candidates

It is suggested that accelerated vaccination schedules with a recombinant hepatitis B vaccine are safe and well-tolerated, but only achieve poor seroconversion rates in OLT candidates.
Wolters Kluwer (opens in a new tab)

Is stenting necessary after balloon dilation of post-transplantation biliary strictures? Results of a prospective comparative study

This data presents a clear picture of the architecture of the immune system in the context of chronic disease and shows clear patterns of decline in the number of immune-related adverse events and disease-related deaths.
Thieme (opens in a new tab)

Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis.

PC and LPC profiles being similar in patients with or without sclerosing cholangitis, these phospholipids are likely not of major pathogenetic importance in this disease group.
PDF (opens in a new tab)
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