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The nasal methylome as a biomarker of asthma and airway inflammation in children

In epigenome-wide association studies for asthma and other airway traits using nasal swabs, the authors identify differentially methylated CpGs that highlight genes involved in TH2 response.
Springer Nature (opens in a new tab)

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Meta-analysis of Illumina’s HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section identified enrichment for biological processes critical to embryonic development.
Springer Nature (opens in a new tab)

Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic in utero

The hypothesis that mercury may be contributing to epigenetic variability and immune cell proportion changes is supported, and it is suggested that in utero exposure to mercury and arsenic, even at low levels, may interact to impact the epigenome.
Taylor & Francis (opens in a new tab)

Plasma Concentrations of Per- and Polyfluoroalkyl Substances at Baseline and Associations with Glycemic Indicators and Diabetes Incidence among High-Risk Adults in the Diabetes Prevention Program…

There was limited evidence suggesting that PFAS concentrations are associated with diabetes incidence or changes in glycemic indicators during the follow-up period, but several PFAS were cross-sectionally associated with small differences in markers of insulin secretion and β-cell function.
PubMed (opens in a new tab)

Exposure to Low Levels of Lead in Utero and Umbilical Cord Blood DNA Methylation in Project Viva: An Epigenome-Wide Association Study

Prenatal low-level lead exposure was associated with newborn DNA methylation, particularly in female infants, according to Project Viva, a prospective U.S. prebirth cohort with relatively low levels of lead exposure.
PubMed (opens in a new tab)

Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood

Evaluating associations of maternal prenatal antidepressant use, anxiety, and depression with cord blood DNA methylation across the genome at birth and test for persistence of associations in early and mid-childhood blood DNA finds the ZNF575 gene is involved in transcriptional regulation but specific functions are largely unknown.
Springer Nature (opens in a new tab)

Association of Periconception Paternal Body Mass Index With Persistent Changes in DNA Methylation of Offspring in Childhood

This cohort study of 429 father-mother-infant triads found that paternal body mass index at the time of conception was associated with both offspring birth weight and epigenome-wide DNA methylation patterns in offspring at birth, age 3 years, and age 7 years.
PubMed (opens in a new tab)

Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood

Cord blood methylation at the PON1 locus predicted lower cognitive test scores measured during early childhood and may modulate mercury toxicity in humans and might serve as a biomarker of exposure and disease susceptibility.
Springer Nature (opens in a new tab)

Blood DNA Methylation Biomarkers of Cumulative Lead Exposure in Adults

DNA methylation-based lead biomarkers are novel tools that can be used to reconstruct decades’ worth of individual cumulative lead exposure using only blood DNA methylation profiles and may help identify the consequences of cumulative exposure.
Springer Nature (opens in a new tab)

Socioeconomic status and DNA methylation from birth through mid-childhood: a prospective study in Project Viva.

Low prenatal SES was associated with methylation at CpG sites near ACSF3, TNRC6C-AS1, MTMR4 and LRRN4, and persisted into early childhood.
PubMed (opens in a new tab)
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