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Day 3 embryo selection by metabolomic profiling of culture medium with near-infrared spectroscopy as an adjunct to morphology: a randomized controlled trial.

The live birth rate after embryo selection by NIR spectroscopy and morphology is not significantly different compared with the liveBirth rate after embryos were selected by morphology alone, and is probably selected for a better prognosis patient group.
PubMed (opens in a new tab)

Predictive value of sperm morphology and progressively motile sperm count for pregnancy outcomes in intrauterine insemination.

Intrauterine insemination is especially relevant for couples with moderate male factor infertility (sperm morphology ≤4%, NIPMS 5-10 million), however, the predictive power of these sperm parameters is rather low in the multivariable model.
PubMed (opens in a new tab)

Clinical outcomes of uninterrupted embryo culture with or without time-lapse-based embryo selection versus interrupted standard culture (SelecTIMO): a three-armed, multicentre, double-blind,…

Neither time-lapse-based embryo selection using the EEVA test nor uninterrupted culture conditions in a time- lapse incubator improved clinical outcomes compared with routine methods.
PubMed (opens in a new tab)

Metabolomic profiling of culture media by near infrared spectroscopy as an adjunct to morphology for selection of a single day 3 embryo to transfer in ivf: a double blind randomised trial

This double blind randomised trial shows that day 3 embryo selection with a NIR spectrometer as an addition to morphology is not able to improve clinical pregnancy rates.
Publisher (opens in a new tab)

No evidence that embryo selection by near-infrared spectroscopy in addition to morphology is able to improve live birth rates: results from an individual patient data meta-analysis.

No evidence is found that NIR spectroscopy of spent embryo culture media in its current form can be used in daily practice to improve live birth rates, and the IPD MA indicates that the live birth rate after embryo selection by NIR Spectroscopy and morphology is not significantly different compared with the liveBirth rate after embryos selection by morphology alone.
PubMed (opens in a new tab)

Embryology Day 3 embryo selectionbymetabolomic profiling of culture medium with near-infrared spectroscopy as an adjunct to morphology : a randomized controlled trial

The liveBirth rate after embryo selection by NIR spectroscopy and morphology is not significantly different compared with the live birth rate after embryos were selected by morphology alone.

Microfluidic protocol for in vitro culture of human embryos

Blastocyst rates show no statistical difference between the two culture groups, while the embryo distribution shifts towards higher quality blastocysts in the microfluidic group.

The inconvenient reality of AI-assisted embryo selection in IVF

A new study reveals that the inflated expectations of new technologies are not always justified, and artificial intelligence is being hyped for its potential to revolutionize assisted reproduction, including embryo selection.
Springer Nature (opens in a new tab)

Time-lapse imaging systems for embryo incubation and assessment to improve reproductive outcomes in women undergoing in vitro fertilisation: study protocol for an individual participant data…

The research proposal for evidence synthesis using individual participant data meta-analysis will provide greater power than aggregate meta-analysis to detect differential treatment effects for effectiveness and safety and safety outcomes across three comparisons.
BMJ (opens in a new tab)

Representation of study in recent RBMO Commentary.

PubMed (opens in a new tab)
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