wortmannin

Known as: (1 Alpha,11 alpha)-11-(acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan- 3,7,17-trione, (1S,6bR,9aS,11R,11bR)-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 2-Oxaandrosta-5,8-dieno[6,5,4-bc]furan-3,7,17-trione, 11-(acetyloxy)-1-(methoxymethyl)-, (1.alpha.,11.alpha.)- 
A potent fungal metabolite isolated from Penicillium wortmannin that selectively inhibits phosphatidylinositol 3-kinase and affects the signal… (More)
National Institutes of Health

Papers overview

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Highly Cited
2000
Highly Cited
2000
The specific phosphoinositide 3-kinase (PI3K) inhibitors wortmannin and LY294002 have been invaluable tools for elucidating the… (More)
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Highly Cited
2000
Highly Cited
2000
The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine… (More)
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Highly Cited
1998
Highly Cited
1998
Members of the phosphatidylinositol-3 kinase related kinase (PIKK) family function in both cell cycle progression and DNA damage… (More)
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Highly Cited
1997
Highly Cited
1997
Recent studies indicate that phosphatidylinositol 3-kinase is essential in the regulation of many processes dependent on membrane… (More)
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Highly Cited
1996
Highly Cited
1996
Hypertension is associated with insulin-resistant states such as diabetes and obesity. Nitric oxide (NO) contributes to… (More)
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Highly Cited
1996
Highly Cited
1996
The immunosuppressant, rapamycin, inhibits cell growth by interfering with the function of a novel kinase, termed mammalian… (More)
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Highly Cited
1994
Highly Cited
1994
Phosphatidylinositol-3-kinase is an important enzyme for intracellular signaling. The microbial product wortmannin and some of… (More)
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Highly Cited
1994
Highly Cited
1994
Significant activity of phosphatidylinositol 3-kinase (PI 3-kinase) was detected in the membrane fractions, or in the… (More)
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Highly Cited
1993
Highly Cited
1993
Phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) is rapidly produced upon exposure of neutrophils to the chemoattractant N… (More)
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Highly Cited
1992
Highly Cited
1992
We have found that a fungal strain, Talaromyces wortmannin KY12420, produces a potent inhibitor of smooth muscle myosin light… (More)
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