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voriconazole

Known as: VCZ, (R-(R*,s*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol, Voriconazolum 
A synthetic triazole with antifungal activity. Voriconazole selectively inhibits 14-alpha-lanosterol demethylation in fungi, preventing the… 
National Institutes of Health

Related topics

Related topics

35 relations

Broader (2)

14-alpha Demethylase InhibitorsCytochrome P-450 CYP3A Inhibitors
Antifungal AgentsAspergillosisAzolesBarbiturates

Narrower (2)

UK 109,496Vfend

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Sentinel surveillance of invasive candidiasis in Spain: epidemiology and antifungal susceptibility.
2010
2010
Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives.
2010
2010
Positive Result of the Aspergillus Galactomannan Antigen Assay Using Bronchoalveolar Lavage Fluid from a Patient with an Invasive Infection Due to Lichtheimia ramosa
Positive galactomannan antigen (GM) test results with serum by the Platelia Aspergillus assay (Bio-Rad, Marnes-La-Coquette… 
Highly Cited
2007
Highly Cited
2007
Update on the treatment of disseminated fusariosis: Focus on voriconazole
Invasive fungal infections are a major cause of morbidity and mortality in immunocompromised patients, such as subjects with… 
Highly Cited
2005
Highly Cited
2005
Comparison of Two Probes for Testing Susceptibilities of Pathogenic Yeasts to Voriconazole, Itraconazole, and Caspofungin by Flow Cytometry
ABSTRACT A cytometric approach to determine the susceptibilities of Candida spp. and Cryptococcus neoformans to voriconazole… 
2005
2005
Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry
Abstract A convenient liquid chromatography-tandem mass spectrometry method for the quantification of the triazole antifungal… 
Highly Cited
2004
Highly Cited
2004
In vitro interactions of licensed and novel antifungal drugs against Fusarium spp.
2003
2003
Effect of increasing inoculum sizes of Aspergillus hyphae on MICs and MFCs of antifungal agents by broth microdilution method.
1999
1999
Antifungal activity of the new azole UK‐109, 496 (voriconazole)
The in vitro activity of voriconazole fully includes Aspergillus, and also emerging moulds like Fusarium, Pseudallescheria boydii… 
Highly Cited
1998
Highly Cited
1998
Activity of Voriconazole Combined with Neutrophils or Monocytes against Aspergillus fumigatus: Effects of Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor
ABSTRACT Voriconazole (VCZ) was tested for antifungal activity againstAspergillus fumigatus hyphae alone or in combination with… 
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