voriconazole

Known as: VCZ, (R-(R*,s*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol, Voriconazolum 
A synthetic triazole with antifungal activity. Voriconazole selectively inhibits 14-alpha-lanosterol demethylation in fungi, preventing the… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
BACKGROUND Voriconazole is the therapy of choice for aspergillosis and a new treatment option for candidiasis. Liver disease, age… (More)
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Highly Cited
2006
Highly Cited
2006
We report on 28 patients who underwent voriconazole monitoring because of disease progression or toxicity. A relationship (P<0… (More)
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Review
2006
Review
2006
Voriconazole is the first available second-generation triazole with potent activity against a broad spectrum of clinically… (More)
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Highly Cited
2005
Highly Cited
2005
The mortality of central nervous system (CNS) aspergillosis approaches 100%, requiring improved therapies. Voriconazole gives… (More)
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Highly Cited
2004
Highly Cited
2004
Infection with voriconazole-resistant fungi may become problematic, because organisms with decreased susceptibility have been… (More)
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Highly Cited
2003
Highly Cited
2003
Treatments for invasive fungal infections remain unsatisfactory. We evaluated the efficacy, tolerability, and safety of… (More)
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Highly Cited
2002
Highly Cited
2002
R AOUL H ERBRECHT , M.D., D AVID W. D ENNING , F.R.C.P., T HOMAS F. P ATTERSON , M.D., J OHN E. B ENNETT , M.D., R EGINALD E. G… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Patients with neutropenia and persistent fever are often treated empirically with amphotericin B or liposomal… (More)
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Highly Cited
2002
Highly Cited
2002
To evaluate the efficacy and safety of voriconazole in acute invasive aspergillosis (IA), an open, noncomparative multicenter… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Voriconazole is a broad-spectrum triazole that is active against aspergillus species. We conducted a randomized trial… (More)
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