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vintafolide

Known as: Folate-Vinca Alkaloid Conjugate EC145 
A water-soluble, folate-receptor-targeted conjugate of folate and the vinca alkaloid desacetylvinblastine monohydrazide (DAVLBH) with potential… 
National Institutes of Health

Related topics

Related topics

6 relations
EC145Microtubule ProcessNCIt Antineoplastic Agent TerminologyNegative Regulation of Cell Cycle

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
A phase 1 dose-escalation study of the folic acid-tubulysin small molecule drug conjugate (SMDC) folate-tubulysin EC1456 in advanced cancer patients.
2585Background: The folate receptor (FR) is highly expressed in several epithelial cancers (e.g. ovarian, NSCLC) but is expressed… 
Review
2015
Review
2015
Cancer Stratification by Molecular Imaging
The lack of specificity of traditional cytotoxic drugs has triggered the development of anticancer agents that selectively… 
2014
2014
Rational Combination Therapy of Vintafolide (EC145) with Commonly Used Chemotherapeutic Drugs
Purpose: When evaluated in patients with ovarian and other cancer, vintafolide (EC145), a potent folate-targeted vinca alkaloid… 
2014
2014
A New Generation of Cell-Targeted Drugs for Cancer Treatment
2014
2014
Abstract 832: Pre-clinical development of EC1456: A potent Folate targeted Tubulysin SMDC
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Folate targeted small molecule drug conjugates (SMDC) have… 
2013
2013
Structural and functional insights on folate receptor α (FRα) by homology modeling, ligand docking and molecular dynamics.
2013
2013
Gynaecological cancer: Vintafolide—targeting the folate receptor with a cytotoxic offers hope
Gynaecological cancer: Vintafolide—targeting the folate receptor with a cytotoxic offers hope 
2013
2013
Abstract 5502: Vintafolide: a first-in-class small molecule drug conjugate targeting folate receptor positive tumors.
Targeted anti-cancer therapies offer the promise of more efficacious treatments with fewer side effects. Vintafolide (also known… 
2012
2012
Biotech weathers 2Q12 slump
2003
2003
Flight Testing of the Eurocopter EC145
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