verticillins

Precursor-directed biosynthesis was used to generate a series of fluorinated verticillins. The biosynthesis of these… Expand

Verticillins are a group of epipolythiodioxopiperazine alkaloids that have displayed potent cytotoxicity. To evaluate their… Expand

Pancreatic ductal adenocarcinoma (PDAC) has the most dismal prognosis among all major solid malignancies, with five-year survival… Expand

Objective The heterogeneity of soft tissue sarcoma (STS) represents a major challenge for the development of effective… Expand

The Fas–FasL effector mechanism plays a key role in cancer immune surveillance by host T cells, but metastatic human colon… Expand

Drug resistance is a major cause of failure in cancer chemotherapy. Therefore, identification and combined use of adjuvant… Expand

Five new verticillin-type epipolysulfanyldioxopiperazines, gliocladine A (1), B (2), C (3), D (4), and E (5), were isolated from… Expand

The HL-60 cell line, derived from a patient with acute promyelocytic leukemia, is a widely used model system to study the… Expand

Four new compounds (1-4) have been isolated from solid-substrate fermentation cultures of the sclerotial mycoparasite Gliocladium… Expand

The stereostructure of a new antibiotic, verticillin A has been elucidated by chemical and physicochemical methods.