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velnacrine

Known as: 1-Acridinol, 9-amino-1,2,3,4-tetrahydro-, 9-amino-1,2,3,4-tetrahydroacridin-1-ol, 1-hydroxytacrine 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Cholinesterase InhibitorsTacrine

Narrower (2)

HP 029velnacrine maleate
analogs & derivatives

Papers overview

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2012
2012
Pharmacokinetics and brain dispositions of tacrine and its major bioactive monohydroxylated metabolites in rats.
2004
2004
Inhibition of murine cytochrome P4501A by tacrine: in vitro studies.
Tacrine, a cholinesterase inhibitor, was approved for the treatment of Alzheimer's disease. Oxidative metabolism of tacrine… 
1999
1999
Plasma tacrine concentrations are significantly increased by concomitant hormone replacement therapy
In vitro results suggest that the synthetic hormones used in postmenopausal hormone replacement therapy (HRT) may be significant… 
1996
1996
Effect of tetrahydroaminoacridine on sleep in healthy subjects
1996
1996
Inhibition of tacrine oral clearance by cimetidine
1996
1996
Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.
Discrepancies in urinary metabolic profiles in rats administered tacrine (1) suggested the presence of an unidentified metabolite… 
Highly Cited
1995
Highly Cited
1995
Determination of human hepatic cytochrome P4501A2 activity in vitro use of tacrine as an isoenzyme-specific probe.
Oxidative metabolism of the cognition activator tacrine (1,2,3,4-tetrahydro-9-aminoacridine) is thought to be catalyzed by… 
1994
1994
Simultaneous determination of tacrine and 1-hydroxy-, 2-hydroxy-, and 4-hydroxytacrine in human plasma by high-performance liquid chromatography with fluorescence detection.
An analytical method was developed for the simultaneous reversed-phase (cyano) high-performance liquid chromatographic… 
1990
1990
Identification of the urinary metabolites of tacrine in the rat.
Tacrine (THA) is a potent cholinesterase inhibitor being studied for the treatment of Alzheimer's disease. The metabolism and… 
1990
1990
Multiple Dose Pharmacokinetics, Safety, and Tolerance of Velnacrine (HP 029) in Healthy Elderly Subjects: A Potential Therapeutic Agent for Alzheimer's Disease
The pharmacokinetics, safety, and tolerance of 1,2,3,4‐tetrahydro‐9‐aminoacridin‐1‐ol‐ maleate (HP 029) a potential therapeutic… 
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