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valproic acid glucuronide

Known as: VPAG 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2017
012319942017

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Valproic Acid
analogs & derivatives

Related mentions per year

Related mentions per year

1953-2018
1960198020002020
valproic acid glucuronide
Valproic Acid
analogs & derivatives

Papers overview

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2012
2012
Periaqueductal gray matter modulates the hypercapnic ventilatory response
The periaqueductal gray (PAG) is a midbrain structure directly involved in the modulation of defensive behaviors. It has direct… (More)
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2011
2011
Inhibition mechanism of carbapenem antibiotics on acylpeptide hydrolase, a key enzyme in the interaction with valproic acid.
We have reported that inhibition of acylpeptide hydrolase (APEH), identified as valproic acid glucuronide hydrolase in human… (More)
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2010
2010
Identification of valproic acid glucuronide hydrolase as a key enzyme for the interaction of valproic acid with carbapenem antibiotics.
Plasma levels of valproic acid (VPA) are decreased by concomitant use with carbapenem antibiotics, such as panipenem (PAPM). One… (More)
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2010
2010
Characterization of inhibitory effect of carbapenem antibiotics on the deconjugation of valproic acid glucuronide.
Serum concentrations of valproic acid (VPA) are markedly decreased by coadministration of carbapenem antibiotics (CBPMs… (More)
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2010
2010
L-allylglycine dissociates the neural substrates of fear in the periaqueductal gray of rats.
The dorsal (dPAG) and ventral (vPAG) regions of the periaqueductal gray are well known to contain the neural substrates of fear… (More)
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2009
2009
Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10.
Valproic acid (VPA) is a widely used anticonvulsant that is also approved for mood disorders, bipolar depression, and migraine… (More)
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2009
2009
Behavioral Consequences of Delta-Opioid Receptor Activation in the Periaqueductal Gray of Morphine Tolerant Rats
Chronic morphine administration shifts delta-opioid receptors (DORs) from the cytoplasm to the plasma membrane. Given that… (More)
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2007
2007
Kinetics of valproic acid glucuronidation: evidence for in vivo autoactivation.
Sigmoidal or autoactivation kinetics has been observed in vitro for both cytochrome P450- and UDP-glucuronosyltransferase… (More)
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2003
2003
Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM.
It is well established that the vanilloid receptor, VR1, is an important peripheral mediator of nociception. VR1 receptors are… (More)
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2002
2002
Inhibition of tubulin assembly and covalent binding to microtubular protein by valproic acid glucuronide in vitro.
Acyl glucuronides are reactive metabolites of carboxylate drugs, able to undergo a number of reactions in vitro and in vivo… (More)
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