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vacquinol-1

 
National Institutes of Health

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NSC13316

Broader (2)

PiperidinesQuinolines

Papers overview

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2019
2019
Mitophagy-Related Cell Death Mediated by Vacquinol-1 and TRPM7 Blockade in Glioblastoma IV
Glioblastoma IV (GBM) is one of the deadliest malignant diseases in adults and is characterized by a high mutation rate and… Expand
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2019
2019
Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro.
AIM To investigate anti-liver fibrosis effects of Salvianolic acid B (Sal B) from Salvia miltiorrhiza Bunge involved mitogen… Expand
2019
2019
Screening of kinase inhibitors downregulating PD-L1 expression via on/in cell quantitative immunoblots.
The interaction of programmed death-1 (PD-1) and it's ligands (PD-L1) is an important immune checkpoint and blockade of PD-1/PD… Expand
2019
2019
Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide
Macropinocytosis is a clathrin-independent endocytosis of extracellular fluid that may contribute to cancer aggressiveness… Expand
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2018
2018
Evaluating vacquinol-1 in rats carrying glioblastoma models RG2 and NS1
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, and available experimental and routine therapies… Expand
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2018
2018
Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell.
Vacquinol‑1 (Vacq), a quinolone derivative, has recently been reported to display potent antitumor effects in glioblastomas by… Expand
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2017
2017
Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP
Glioblastomas (GBM) are the most malignant brain tumors in humans and have a very poor prognosis. New therapeutic options are… Expand
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2016
2016
The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features.
Glioblastoma remains an incurable brain cancer. Drugs developed in the past 20 years have not improved the prognosis for patients… Expand
2015
2015
Identification of compounds that target glioma initiating cells
Glioblastoma multiforme is a common form of brain tumor that leads to debilitating effects despite the current regiment of… Expand
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Highly Cited
2014
Highly Cited
2014
RETRACTED: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule
Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer with marginal life expectancy. Based on the assumption… Expand
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